Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | COMT | P21964 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 2/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
| ▸ | TYMS | P04818 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6940851 | 0.87 | TNKS (0.39) | CDK5CDK5R1COMTTNKS | |
| SCHEMBL7739889 | 0.82 | APP (0.35) | APPCDK5CDK5R1AKR1C3AKR1C2 | |
| SCHEMBL7739895 | 0.82 | AKR1C3 (0.36) | APPCDK5CDK5R1AKR1C3AKR1C2 | |
| SCHEMBL8828097 | 0.77 | DAO (0.37) | — | |
| SCHEMBL7741405 | 0.77 | NTRK1 (0.38) | — | |
| SCHEMBL7740551 | 0.76 | PRKAG1 (0.43) | — | |
| SCHEMBL6935464 | 0.71 | PRKAG1 (0.43) | — | |
| SCHEMBL7740618 | 0.71 | PTGES (0.38) | AKR1C3AKR1C2TNKS | |
| SCHEMBL7740617 | 0.70 | PTGES (0.36) | CDK5CDK5R1TNKSTYMS | |
| SCHEMBL7742754 | 0.70 | PRKAG1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420386-B1 | SPINAL TRAUMATISM, EPILEPSY, CHRONIC NEURODEGENERATIVE DISEASES SUCH AS ALZHEIMER'S DISEASE, SCHIZOPHRENIA, LATERAL AMYOTROPHIC SCLEROSIS OR HUNTINGTON'S CHOREA. | LES LABORATORIES SERVIER (FR) | 2002-07-16 | — | — | US | disclosed |