Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7710689 | 1.00 | TSHR (0.57) | — | |
| SCHEMBL7704836 | 1.00 | TSHR (0.57) | — | |
| SCHEMBL10364806 | 1.00 | — | — | |
| SCHEMBL29880995 | 1.00 | TSHR (0.57) | — | |
| SCHEMBL10757626 | 1.00 | TSHR (0.57) | — | |
| SCHEMBL29558624 | 1.00 | TSHR (0.57) | — | |
| SCHEMBL11353224 | 1.00 | TSHR (0.57) | — | |
| SCHEMBL9328424 | 1.00 | TSHR (0.57) | — | |
| SCHEMBL7738518 | 0.96 | — | — | |
| SCHEMBL29407263 | 0.96 | TSHR (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240415847-A1 | BETA-LACTAMASE INHIBITORS AND USES THEREOF | ARIXA PHARMACEUTICALS, INC. (US) | 2024-12-19 | — | — | US | disclosed |
| EP-3860999-B9 | DERIVATIVES OF RELEBACTAM AND USES THEREOF | ARIXA PHARMACEUTICALS INC (US) | 2024-08-14 | — | — | EP | disclosed |
| EP-3860999-B1 | DERIVATIVES OF RELEBACTAM AND USES THEREOF | ARIXA PHARMACEUTICALS INC (US) | 2024-06-05 | — | — | EP | disclosed |
| EP-3625233-B9 | 3-(((((2S,5R)-2-CARBAMOYL-7-OXO-1,6-DIAZABICYCLO[3.2.1]OCTAN-6-YL)OXY)SULFONYL)OXY)-2,2-DIMETHYLPROPANOATE DERIVATIVES AND RELATED COMPOUNDS AS PERORALLY ADMINISTERED PROFRUGS OF BETA-LACTAMASE INHIBITORS FOR TREATING BACTERIAL INFECTIONS | ARIXA PHARMACEUTICALS INC (US) | 2023-10-25 | — | — | EP | disclosed |
| EP-3625233-B1 | 3-(((((2S,5R)-2-CARBAMOYL-7-OXO-1,6-DIAZABICYCLO[3.2.1]OCTAN-6-YL)OXY)SULFONYL)OXY)-2,2-DIMETHYLPROPANOATE DERIVATIVES AND RELATED COMPOUNDS AS PERORALLY ADMINISTERED PROFRUGS OF BETA-LACTAMASE INHIBITORS FOR TREATING BACTERIAL INFECTIONS | ARIXA PHARMACEUTICALS INC (US) | 2023-07-12 | — | — | EP | disclosed |
| US-20230201218-A1 | BETA-LACTAMASE INHIBITORS AND USES THEREOF | ARIXA PHARMACEUTICALS, INC. (US) | 2023-06-29 | — | — | US | disclosed |
| EP-3676247-B1 | AZTREONAM DERIVATIVES AND USES THEREOF | ARIXA PHARMACEUTICALS INC (US) | 2023-03-08 | — | — | EP | disclosed |
| CN-110662746-B | Compounds as orally administered prodrugs of beta-lactamase inhibitors, pharmaceutical compositions thereof and use for treating bacterial infections | 阿里萨制药有限公司 | 2022-08-19 | — | — | CN | disclosed |
| US-11180500-B2 | Derivatives of relebactam and uses thereof | ARIXA PHARMACEUTICALS, INC. (US) | 2021-11-23 | — | — | US | disclosed |
| US-20210009580-A1 | AZTREONAM DERIVATIVES AND USES THEREOF | ARIXA PHARMACEUTICALS, INC. | 2021-01-14 | — | — | US | disclosed |
| CN-101238155-A | Method of taking (meth)acrylic ester polymer out of liquid reaction mixture | KURARAY CO (JP) | 2008-08-06 | — | — | CN | disclosed |
| CN-100355827-C | Process for the preparation of vinylic polymers, polymerization initiator for vinylic monomers, and styrene resin composition | ASAHI CHEMICAL IND (JP) | 2007-12-19 | — | — | CN | disclosed |
| CN-1680476-A | Process for the preparation of vinylic polymers, polymerization initiator for vinylic monomers, and styrene resin composition | ASAHI CHEMICAL IND (JP) | 2005-10-12 | — | — | CN | disclosed |
| CN-1208353-C | Process for producing vinyl polymer, vinyl monomer polymerization initiator and styrene resin composition | ASAHI CHEMICAL IND (JP) | 2005-06-29 | — | — | CN | disclosed |
| CN-1118496-C | Preparation of conjugated diene and/or monovinyl arene polymer | SHENGJIE INDUSTRY CO LTD JIANG (CN) | 2003-08-20 | — | — | CN | disclosed |
| CN-1118493-C | Process for preparing atactic copolymer of conjugated diene and monovinyl arylhydrocarbon | RES INST OF YANSHAN PETRO CHEM (CN) | 2003-08-20 | — | — | CN | disclosed |
| US-6429273-B1 | ANIONIC POLYMERIZATION OF STYRENE USING MAGNESIUM AND ALKALI METAL-BASED INITIATORS; CONTROLLED MOLECULAR WEIGHT DISTRIBUTION; CONTROLLABLE RATE PREVENTS RUNAWAY REACTION; EXCELLENT MOLDING CHARACTERISTICS | ASAHI KASEI KABUSHIKI KAISHA (JP) | 2002-08-06 | — | — | US | disclosed |
| CN-1269371-A | Preparation of conjugated diene and/or monovinyl arene polymer | JIANGSU SHENGJIE INDUSTRY CO L (CN) | 2000-10-11 | — | — | CN | disclosed |
| CN-1264714-A | Process for preparing atactic copolymer of conjugated diene and monovinyl arylhydrocarbon | RES INST OF YANSHAN PETRO CHEM (CN) | 2000-08-30 | — | — | CN | disclosed |
| CN-1216049-A | Process for producing vinyl polymer, vinyl monomer polymerization initiator and styrene resin composition | ASAHI CHEMICAL IND (JP) | 1999-05-05 | — | — | CN | disclosed |