Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.49 |
| ▸ | EP300 | Q09472 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GRM6 | O15303 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7761536 | 0.95 | OPRD1 (0.48) | OPRD1ALOX5EP300PTGS2KDM4E | |
| SCHEMBL7756786 | 0.94 | OPRD1 (0.47) | OPRD1ALOX5EP300PTGS2 | |
| SCHEMBL678077 | 0.93 | ALOX5 (0.56) | OPRD1ALOX5EP300PTGS2KDM4E | |
| SCHEMBL7760704 | 0.89 | OPRD1 (0.49) | OPRD1ALOX5EP300KDM4ERAB9A | |
| SCHEMBL14195275 | 0.88 | ALOX5 (0.51) | OPRD1ALOX5EP300PTGS2 | |
| SCHEMBL7760695 | 0.86 | OPRD1 (0.56) | OPRD1EP300PTGS2KDM4EALDH1A1 | |
| SCHEMBL7902764 | 0.85 | OPRD1 (0.54) | OPRD1EP300PTGS2KDM4EALDH1A1 | |
| SCHEMBL7899189 | 0.84 | OPRD1 (0.51) | OPRD1EP300KDM4ERAB9AALDH1A1 | |
| SCHEMBL17833490 | 0.80 | MAPK14 (0.42) | OPRD1ALOX5EP300PTGS2KDM4E | |
| SCHEMBL5599629 | 0.78 | OPRD1 (0.53) | OPRD1EP300KDM4ERAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0728755-B1 | Thiophene compounds, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-04-11 | — | — | EP | claimed |
| US-RE37078-E1 | Thiophene compounds | ADIR ET COMPAGNIE (FR) | 2001-02-27 | — | — | US | claimed |
| EP-0728755-A1 | Thiophene compounds, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-08-28 | — | — | EP | claimed |
| JP-8253470-A | — | — | None | — | — | JP | disclosed |
| EP-0728755-B1 | Thiophene compounds, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-04-11 | — | — | EP | disclosed |
| US-RE37078-E1 | Thiophene compounds | ADIR ET COMPAGNIE (FR) | 2001-02-27 | — | — | US | disclosed |
| US-5705525-A | ANTIINFLAMMATORY AGENTS AND TREATMENT OF RHEUMATIC DISEASES | ADIR ET COMPAGNIE (FR) | 1998-01-06 | — | — | US | disclosed |
| JP-H08253470-A | NEW THIOPHENE COMPOUND, ITS PRODUCTION AND PHARMACEUTICAL COMPOSITION CONTAINING THE COMPOUND | ADIR | 1996-10-01 | — | — | JP | disclosed |
| EP-0728755-A1 | Thiophene compounds, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-08-28 | — | — | EP | disclosed |