Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.56 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.50 |
| ▸ | EP300 | Q09472 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GRM6 | O15303 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14195275 | 0.94 | ALOX5 (0.51) | ALOX5OPRD1EP300PTGS2MAPK14 | |
| SCHEMBL7756777 | 0.93 | OPRD1 (0.52) | ALOX5OPRD1EP300PTGS2RAB9A | |
| SCHEMBL7761536 | 0.88 | OPRD1 (0.48) | ALOX5OPRD1EP300PTGS2RAB9A | |
| SCHEMBL17833490 | 0.88 | MAPK14 (0.42) | ALOX5OPRD1EP300PTGS2MAPK14 | |
| SCHEMBL7756786 | 0.87 | OPRD1 (0.47) | ALOX5OPRD1EP300PTGS2MAPK14 | |
| SCHEMBL5599629 | 0.83 | OPRD1 (0.53) | OPRD1EP300MAPK14RAB9AKDM4E | |
| SCHEMBL7760704 | 0.82 | OPRD1 (0.49) | ALOX5OPRD1EP300RAB9AKDM4E | |
| SCHEMBL7760695 | 0.81 | OPRD1 (0.56) | OPRD1EP300PTGS2KDM4EALDH1A1 | |
| SCHEMBL7902764 | 0.80 | OPRD1 (0.54) | OPRD1EP300PTGS2MAPK14KDM4E | |
| SCHEMBL7899189 | 0.80 | OPRD1 (0.51) | OPRD1EP300MAPK14RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0728755-B1 | Thiophene compounds, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-04-11 | — | — | EP | claimed |
| US-RE37078-E1 | Thiophene compounds | ADIR ET COMPAGNIE (FR) | 2001-02-27 | — | — | US | claimed |
| EP-0728755-A1 | Thiophene compounds, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-08-28 | — | — | EP | claimed |
| US-20220105064-A1 | CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS COMPRISING A FUMARIC ACID ESTER | BIOGEN SWISS MFG GMBH (CH) | 2022-04-07 | — | — | US | disclosed |
| US-11229619-B2 | Controlled release pharmaceutical compositions comprising a fumaric acid ester | BIOGEN SWISS MANUFACTURING GMBH (CH) | 2022-01-25 | — | — | US | disclosed |
| US-20210220318-A1 | CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS COMPRISING A FUMARIC ACID ESTER | FWP IP APS (DK) | 2021-07-22 | — | — | US | disclosed |
| US-11052062-B2 | Controlled release pharmaceutical compositions comprising a fumaric acid ester | BIOGEN SWISS MANUFACTURING GMBH (CH) | 2021-07-06 | — | — | US | disclosed |
| US-20190343787-A1 | CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS COMPRISING A FUMARIC ACID ESTER | FORWARD PHARMA A/S (DK) | 2019-11-14 | — | — | US | disclosed |
| US-20190201368-A1 | CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS COMPRISING A FUMARIC ACID ESTER | BIOGEN SWISS MANUFACTURING GMBH (CH) | 2019-07-04 | — | — | US | disclosed |
| US-20190117613-A1 | CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS COMPRISING A FUMARIC ACID ESTER | BIOGEN SWISS MANUFACTURING GMBH (CH) | 2019-04-25 | — | — | US | disclosed |
| EP-3470064-A1 | CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS COMPRISING A FUMARIC ACID ESTER | FWP IP APS (DK) | 2019-04-17 | — | — | EP | disclosed |
| EP-1951206-A1 | CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS COMPRISING A FUMARIC ACID ESTER | Aditech Pharma AB (SE) | 2008-08-06 | — | — | EP | disclosed |
| EP-1915387-A1 | NOVEL GLUCOPYRANOSE ESTERS AND GLUCOFURANOSE ESTERS OF ALKYL- FUMARATES AND THEIR PHARMACEUTICAL USE | Aditech Pharma AB (SE) | 2008-04-30 | — | — | EP | disclosed |
| EP-1915334-A2 | NOVEL SALTS OF FUMARIC ACID MONOALKYLESTERS AND THEIR PHARMACEUTICAL USE | Aditech Pharma AB (SE) | 2008-04-30 | — | — | EP | disclosed |
| US-20080004344-A1 | Novel Salts of Fumaric Acid Monoalkylesters and Their Pharmaceutical Use | ADITECH PHARMA AB (SE) | 2008-01-03 | — | — | US | disclosed |
| EP-1812374-A1 | NOVEL SALTS OF FUMARIC ACID MONOALKYLESTERS AND THEIR PHARMACEUTICAL USE | Aditech Pharma AB (SE) | 2007-08-01 | — | — | EP | disclosed |
| WO-2007042034-A1 | CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS COMPRISING A FUMARIC ACID ESTER | ADITECH PHARMA AB (SE) | 2007-04-19 | — | — | WO | disclosed |
| WO-2007006307-A2 | NOVEL SALTS OF FUMARIC ACID MONOALKYLESTERS AND THEIR PHARMACEUTICAL USE | ADITECH PHARMA AB (SE) | 2007-01-18 | — | — | WO | disclosed |
| WO-2007006308-A1 | NOVEL GLUCOPYRANOSE ESTERS AND GLUCOFURANOSE ESTERS OF ALKYL- FU MARATES AND THEIR PHARMACEUTICAL USE | ADITECH PHARMA AB (SE) | 2007-01-18 | — | — | WO | disclosed |
| WO-2006050730-A1 | NOVEL SALTS OF FUMARIC ACID MONOALKYLESTERS AND THEIR PHARMACEUTICAL USE | ADITECH PHARMA AB (SE) | 2006-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004344-A1 | Novel Salts of Fumaric Acid Monoalkylesters and Their Pharmaceutical Use | FAH, FH, SLC16A7 | ALOX5 387/4885OPRD1 4876/4885EP300 1162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.