Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | EP300 | Q09472 | 2/20 | 0.43 |
| ▸ | GRM6 | O15303 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7756777 | 0.89 | OPRD1 (0.52) | OPRD1EP300GRM6TDP1KDM4E | |
| SCHEMBL7761536 | 0.85 | OPRD1 (0.48) | OPRD1EP300GRM6KDM4ERAB9A | |
| SCHEMBL7756786 | 0.84 | OPRD1 (0.47) | OPRD1EP300ALOX5 | |
| SCHEMBL7899189 | 0.83 | OPRD1 (0.51) | OPRD1EP300GRM6KDM4ERAB9A | |
| SCHEMBL7760695 | 0.83 | OPRD1 (0.56) | OPRD1EP300KDM4EALDH1A1HSD17B10 | |
| SCHEMBL678077 | 0.82 | ALOX5 (0.56) | OPRD1EP300GRM6KDM4ERAB9A | |
| SCHEMBL7902764 | 0.82 | OPRD1 (0.54) | OPRD1EP300GRM6TDP1KDM4E | |
| SCHEMBL14195275 | 0.78 | ALOX5 (0.51) | OPRD1EP300ALOX5 | |
| SCHEMBL5599629 | 0.75 | OPRD1 (0.53) | OPRD1EP300KDM4ERAB9AALDH1A1 | |
| SCHEMBL8689165 | 0.74 | OPRD1 (0.49) | OPRD1EP300GRM6TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0728755-B1 | Thiophene compounds, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-04-11 | — | — | EP | claimed |
| US-RE37078-E1 | Thiophene compounds | ADIR ET COMPAGNIE (FR) | 2001-02-27 | — | — | US | claimed |
| EP-0728755-A1 | Thiophene compounds, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-08-28 | — | — | EP | claimed |