Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 6/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20224588 | 0.81 | DHFR (0.45) | KDM4ETP53SLC6A2KMT2ATSHR | |
| SCHEMBL15175611 | 0.80 | KDM4E (0.47) | KDM4ETP53KMT2ATSHRMEN1 | |
| SCHEMBL15174746 | 0.80 | TP53 (0.43) | KDM4ETP53SLC6A2KMT2ATSHR | |
| SCHEMBL19930272 | 0.80 | KDM4E (0.40) | KDM4ETP53SLC6A2KMT2ATSHR | |
| SCHEMBL16863757 | 0.78 | TP53 (0.40) | KDM4ETP53SLC6A2KMT2ATSHR | |
| SCHEMBL26596972 | 0.78 | KMT2A (0.36) | KDM4ETP53KMT2AMEN1MAPT | |
| SCHEMBL7638728 | 0.78 | HDAC10 (0.40) | KDM4ETP53KMT2AMEN1MAPT | |
| SCHEMBL16452868 | 0.78 | CYP2A6 (0.41) | KDM4ETP53KMT2AMEN1MAPT | |
| SCHEMBL16345407 | 0.77 | KDM4E (0.39) | KDM4ETP53SLC6A2KMT2ATSHR | |
| SCHEMBL14929532 | 0.75 | KMT2A (0.59) | KDM4EKMT2AMEN1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10919914-B2 | Heterocyclic compounds and uses thereof | INFINITY PHARMACEUTICALS, INC. (US) | 2021-02-16 | — | — | US | disclosed |
| WO-2020123670-A1 | SMALL MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR ACTIVITY AND/OR EXPRESSION AND USES THEREOF | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2020-06-18 | — | — | WO | disclosed |
| US-10568889-B2 | Prostaglandin receptor EP2 antagonists, derivatives, compositions, and uses related thereto | EMORY UNIVERSITY (US) | 2020-02-25 | — | — | US | disclosed |
| EP-3312179-B1 | FUSED-RING OR TRICYCLIC ARYL PYRIMIDINE COMPOUND USED AS KINASE INHIBITOR | NANJING SANHOME PHARMACEUTICAL CO LTD (CN) | 2019-07-10 | — | — | EP | disclosed |
| US-20190135833-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | TWELVE THERAPEUTICS, INC. | 2019-05-09 | — | — | US | disclosed |
| US-10035765-B2 | Nitrogen-containing polycyclic compound and organic light emitting device using same | LG CHEM, LTD. (KR) | 2018-07-31 | — | — | US | disclosed |
| CN-107406431-A | Indole derivatives and preparation method thereof and its purposes in medicine | 浙江海正药业股份有限公司 | 2017-11-28 | — | — | CN | disclosed |
| US-20170283379-A1 | NITROGEN-CONTAINING POLYCYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE USING SAME (AS AMENDED) | LG CHEM, LTD. (KR) | 2017-10-05 | — | — | US | disclosed |
| US-9458145-B2 | Benzimidazole derivatives as bromodomain inhibitors | GILEAD SCIENCES, INC. (US) | 2016-10-04 | — | — | US | disclosed |
| US-9409938-B2 | Tungsten oxo alkylidene complexes for Zselective olefin metathesis | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2016-08-09 | — | — | US | disclosed |
| US-20160009746-A1 | TUNGSTEN OXO ALKYLIDENE COMPLEXES FOR Z SELECTIVE OLEFIN METATHESIS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2016-01-14 | — | — | US | disclosed |
| US-9085595-B2 | Tungsten oxo alkylidene complexes for Z selective olefin metathesis | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-07-21 | — | — | US | disclosed |
| US-20140336190-A1 | BENZIMIDAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS | GILEAD SCIENCES, INC. (US) | 2014-11-13 | — | — | US | disclosed |
| US-20130116434-A1 | TUNGSTEN OXO ALKYLIDENE COMPLEXES FOR Z SELECTIVE OLEFIN METATHESIS | TRUSTEES OF BOSTON COLLEGE (US) | 2013-05-09 | — | — | US | disclosed |
| US-8278327-B2 | PDE10 inhibitors and related compositions and methods | OMEROS CORPORATION (US) | 2012-10-02 | — | — | US | disclosed |
| CN-102272128-A | Modulators of atp-binding cassette transporters | — | 2011-12-07 | — | — | CN | disclosed |
| US-20110021509-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | OMEROS CORPORATION (US) | 2011-01-27 | — | — | US | disclosed |
| US-7786139-B2 | PDE10 inhibitors and related compositions and methods | OMEROS CORPORATION (US) | 2010-08-31 | — | — | US | disclosed |
| US-7550499-B2 | Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-06-23 | — | — | US | disclosed |
| US-20080300240-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | OMEROS CORPORATION (US) | 2008-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080300240-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | PDE10A, PDE9A, PDE7A | KDM4E 2347/4885TP53 3634/4885SLC6A2 974/4885 |
| US-10919914-B2 | Heterocyclic compounds and uses thereof | PIK3CA, PIK3CD, PIK3CB | KDM4E 3893/4885TP53 544/4885SLC6A2 4761/4885 |
| US-20170283379-A1 | NITROGEN-CONTAINING POLYCYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE USING SAME (AS AMENDED) | PER2, CRY1, CRY2 | KDM4E 1594/4885TP53 4455/4885SLC6A2 2647/4885 |
| US-20130116434-A1 | TUNGSTEN OXO ALKYLIDENE COMPLEXES FOR Z SELECTIVE OLEFIN METATHESIS | SOD1, ZRANB2, ZCCHC8 | KDM4E 4640/4885TP53 3118/4885SLC6A2 1934/4885 |
| US-20160009746-A1 | TUNGSTEN OXO ALKYLIDENE COMPLEXES FOR Z SELECTIVE OLEFIN METATHESIS | SOD1, ZRANB2, ZCCHC8 | KDM4E 4640/4885TP53 3118/4885SLC6A2 1934/4885 |
| US-20190135833-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | PIK3CA, PIK3CD, PIK3CB | KDM4E 3893/4885TP53 544/4885SLC6A2 4761/4885 |
| US-10568889-B2 | Prostaglandin receptor EP2 antagonists, derivatives, compositions, and uses related thereto | PTGER2, PTGES2, PTGER1 | KDM4E 3087/4885TP53 3372/4885SLC6A2 4020/4885 |
| US-20140336190-A1 | BENZIMIDAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS | BRD4, BRD3, BRD1 | KDM4E 249/4885TP53 794/4885SLC6A2 4845/4885 |
| US-10035765-B2 | Nitrogen-containing polycyclic compound and organic light emitting device using same | NPM1, PER2, CRY1 | KDM4E 1641/4885TP53 3877/4885SLC6A2 2232/4885 |
| US-20110021509-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | PDE10A, PDE9A, PDE7A | KDM4E 2437/4885TP53 3598/4885SLC6A2 879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.