SCHEMBL7804698

SCHEMBL7804698

O=C(O)c1ccncc1C(=O)c1cc(Cl)ccc1F

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TGFBR1 P36897 2/20 0.47
NUDT1 P36639 1/20 0.45
ALDH1A1 P00352 2/20 0.45
TP53 P04637 1/20 0.45
TSHR P16473 1/20 0.45
CASP1 P29466 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
KDM4C Q9H3R0 8/20 0.42
KDM4E B2RXH2 1/20 0.42
MEN1 O00255 1/20 0.42
KDM6B O15054 1/20 0.42
KDM4A O75164 1/20 0.42
MAPT P10636 1/20 0.42
THRB P10828 1/20 0.42
KMT2A Q03164 1/20 0.42
KDM4D Q6B0I6 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7812042 0.94 TGFBR1 (0.47) TGFBR1NUDT1ALDH1A1TP53TSHR
SCHEMBL7766931 0.87 CES2 (0.47) ALDH1A1KDM4CKDM4EMEN1KDM6B
SCHEMBL9435361 0.84 TGFBR1 (0.48) TGFBR1NUDT1ALDH1A1KDM4CKDM4E
SCHEMBL7772555 0.81 CES2 (0.47) ALDH1A1KDM4CKDM4EMEN1KDM6B
SCHEMBL21056674 0.81 TGFBR1 (0.51) TGFBR1NUDT1ALDH1A1TP53TSHR
SCHEMBL15240530 0.79 KMO (0.50) TGFBR1NUDT1ALDH1A1TP53TSHR
SCHEMBL28072667 0.79 ALDH1A1 (0.50) ALDH1A1TP53TSHRCASP1SMN1; SMN2
SCHEMBL1040762 0.78 NR4A1 (0.62) ALDH1A1TSHRKDM4CKDM4EMEN1
SCHEMBL7816809 0.77 CA1 (0.49) TGFBR1ALDH1A1TP53TSHRCASP1
SCHEMBL30396748 0.77 ALDH1A1 (0.65) ALDH1A1TP53TSHRCASP1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0750619-B1 HETERO-ANNULATED INDAZOLES NOVUSPHARMA SPA (IT) 2001-05-30 EP disclosed
EP-0662076-B1 2-AMINOALKYL-5-AMINOALKYLAMINO SUBSTITUTED ISOQUINOINDAZOLE-6-(2H)-ONES WITH ANTITUMOUR ACTIVITY UNIV VERMONT (US) 2001-04-11 EP disclosed
US-5604246-A HAVING POTENCY AGAINST MULTIDRUG RESISTANT TUMORS BOEHRINGER MANNHEIM ITALIA SPA (IT) 1997-02-18 US disclosed
US-5596097-A ANTITUMOR AGENTS THE UNIVERSITY OF VERMONT (US) 1997-01-21 US disclosed
EP-0750619-A1 HETERO-ANNULATED INDAZOLES BOEHRINGER MANNHEIM ITALIA S.p.A. (IT) 1997-01-02 EP disclosed
US-5519029-A ANTITUMOR AGENTS BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) 1996-05-21 US disclosed
WO-1995024407-A1 HETERO-ANNULATED INDAZOLES BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) 1995-09-14 WO disclosed
EP-0662076-A1 2-AMINOALKYL-5-AMINOALKYLAMINO SUBSTITUTED ISOQUINOINDAZOLE-6-(2H)-ONES WITH ANTITUMOUR ACTIVITY THE UNIVERSITY OF VERMONT (US) 1995-07-12 EP disclosed
WO-1994006795-A1 2-AMINOALKYL-5-AMINOALKYLAMINO SUBSTITUTED ISOQUINOINDAZOLE-6-(2H)-ONES WITH ANTITUMOUR ACTIVITY THE UNIVERSITY OF VERMONT (US) 1994-03-31 WO disclosed