Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | KRAS | P01116 | 1/20 | 0.30 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.30 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.30 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7785470 | 1.00 | TRPM8 (0.32) | TRPM8MAPKAPK2CYP3A4CYP2D6SLC6A2 | |
| SCHEMBL7789259 | 0.90 | ADRB2 (0.35) | TRPM8MAPKAPK2CYP3A4CYP2D6SLC6A2 | |
| SCHEMBL7785573 | 0.90 | ADRB2 (0.35) | TRPM8MAPKAPK2CYP3A4CYP2D6SLC6A2 | |
| SCHEMBL7785234 | 0.90 | MAPKAPK2 (0.34) | MAPKAPK2CYP3A4CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL7780509 | 0.90 | MAPKAPK2 (0.34) | MAPKAPK2CYP3A4CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL7787615 | 0.89 | MAPKAPK2 (0.33) | TRPM8MAPKAPK2CYP3A4CYP2D6SLC6A2 | |
| SCHEMBL7785680 | 0.88 | NPC1 (0.41) | CYP3A4CYP2D6NPC1ALDH1A1SLC6A9 | |
| SCHEMBL7780717 | 0.88 | ALDH1A1 (0.41) | CYP3A4ALDH1A1KRASSOS1LMNA | |
| SCHEMBL7789250 | 0.88 | ALDH1A1 (0.41) | CYP3A4ALDH1A1KRASSOS1LMNA | |
| SCHEMBL7787788 | 0.86 | CASR (0.37) | MAPKAPK2SLC6A2SLC6A4ALDH1A1SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |