Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CDK4 | P11802 | 2/20 | 0.48 |
| ▸ | CCND1 | P24385 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | HAT1 | O14929 | 2/20 | 0.46 |
| ▸ | EP300 | Q09472 | 2/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7785217 | 0.84 | FAAH (0.51) | KMT2ANPC1POLBRAB9AMEN1 | |
| SCHEMBL7785268 | 0.83 | NPC1 (0.45) | KMT2ANPC1POLBRAB9AMEN1 | |
| SCHEMBL7780397 | 0.80 | NPC1 (0.46) | KMT2ANPC1POLBRAB9AMEN1 | |
| SCHEMBL7785046 | 0.80 | TDP1 (0.49) | KMT2ANPC1POLBRAB9AMEN1 | |
| SCHEMBL7780342 | 0.76 | KMT2A (0.54) | KMT2AMEN1MAPTLMNATDP1 | |
| SCHEMBL7789152 | 0.76 | SIGMAR1 (0.53) | KMT2AMEN1LMNATDP1SMN1; SMN2 | |
| SCHEMBL13720170 | 0.75 | NPC1 (0.59) | KMT2ANPC1POLBRAB9AMEN1 | |
| SCHEMBL7789351 | 0.75 | TDP1 (0.41) | KMT2AMEN1MAPTLMNATDP1 | |
| SCHEMBL7787602 | 0.74 | ALDH1A1 (0.44) | KMT2AMEN1MAPTLMNATDP1 | |
| SCHEMBL7787942 | 0.73 | TDP1 (0.49) | KMT2AMEN1MAPTLMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| CN-1287117-A | Cyclobutene derivatives, preparation method and therapeutic use thereof | SANKYO CO (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |