Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7789351 | 0.92 | TDP1 (0.41) | ALDH1A1LMNAGAACYP1A2CYP2D6 | |
| SCHEMBL7780362 | 0.89 | TDP1 (0.50) | ALDH1A1LMNAGAATDP1KMT2A | |
| SCHEMBL7785046 | 0.89 | TDP1 (0.49) | ALDH1A1GAATAAR1TDP1KMT2A | |
| SCHEMBL7789039 | 0.82 | KMT2A (0.46) | ALDH1A1LMNAGAAL3MBTL1TDP1 | |
| SCHEMBL7789152 | 0.82 | SIGMAR1 (0.53) | ALDH1A1LMNAGAATDP1KMT2A | |
| SCHEMBL7787489 | 0.82 | ALDH1A1 (0.39) | ALDH1A1LMNAGAATAAR1CYP1A2 | |
| SCHEMBL7780337 | 0.78 | ALDH1A1 (0.40) | ALDH1A1LMNAGAATAAR1CYP1A2 | |
| SCHEMBL7780342 | 0.78 | KMT2A (0.54) | ALDH1A1LMNATDP1KMT2AMEN1 | |
| SCHEMBL7785107 | 0.77 | ALDH1A1 (0.50) | ALDH1A1LMNAGAACYP1A2CYP2D6 | |
| SCHEMBL7780790 | 0.77 | ALDH1A1 (0.50) | ALDH1A1LMNAGAACYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| CN-1287117-A | Cyclobutene derivatives, preparation method and therapeutic use thereof | SANKYO CO (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |