Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.52 |
| ▸ | SLC6A5 | Q9Y345 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7784878 | 0.92 | ALDH1A1 (0.68) | ALDH1A1GAALMNASLC6A9SLC6A5 | |
| SCHEMBL7787169 | 0.91 | ALDH1A1 (0.58) | ALDH1A1GAALMNASLC6A9SLC6A5 | |
| SCHEMBL7785656 | 0.90 | ALDH1A1 (0.62) | ALDH1A1GAALMNASLC6A9SLC6A5 | |
| SCHEMBL7780394 | 0.81 | ALDH1A1 (0.67) | ALDH1A1GAALMNASLC6A9SLC6A5 | |
| SCHEMBL7785313 | 0.81 | GPR88 (0.49) | ALDH1A1GAALMNACYP3A4KMT2A | |
| SCHEMBL7789410 | 0.81 | ALDH1A1 (0.57) | ALDH1A1GAALMNASLC6A9SLC6A5 | |
| SCHEMBL7788988 | 0.80 | ALDH1A1 (0.47) | ALDH1A1GAALMNAKMT2AMEN1 | |
| SCHEMBL7780375 | 0.79 | KMT2A (0.42) | ALDH1A1GAALMNACYP3A4KMT2A | |
| SCHEMBL7780556 | 0.79 | ALDH1A1 (0.44) | ALDH1A1GAALMNAKMT2ATP53 | |
| Hydrochloric Acid SCHEMBL7785333 | 0.78 | ALDH1A1 (0.74) | ALDH1A1GAALMNASLC6A9SLC6A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| CN-1287117-A | Cyclobutene derivatives, preparation method and therapeutic use thereof | SANKYO CO (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |