Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.47 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.47 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.47 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.47 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.47 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.47 |
| ▸ | BDKRB2 known ✓ | P30411 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | TP53 | P04637 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | APAF1 | O14727 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | RAD52 | P43351 | 3/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | UBE2N | P61088 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL11423879 | 0.99 | KMT2A (0.48) | KMT2AMEN1TP53SMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9724638 | 0.93 | MEN1 (0.40) | KMT2AMEN1TP53SMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9398193 | 0.85 | GABRA1 (0.35) | SMN1; SMN2ALDH1A1MAPTLMNAADRB2 | |
| Hydrochloric Acid SCHEMBL4492741 | 0.83 | MEN1 (0.48) | KMT2AMEN1TP53SMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL237444 | 0.82 | MEN1 (0.53) | KMT2AMEN1TP53SMN1; SMN2ALDH1A1 | |
| Benzododecinium SCHEMBL9013105 | 0.80 | MEN1 (0.42) | KMT2AMEN1TP53SMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10939133 | 0.78 | MEN1 (0.63) | KMT2AMEN1TP53SMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8958601 | 0.75 | KDM4E (0.37) | KMT2AMEN1TP53SMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5156049 | 0.74 | SMN1; SMN2 (0.70) | KMT2AMEN1TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL1013749 | 0.73 | GABRA1 (0.36) | ALDH1A1MAPTTDP1CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0034126-B1 | COSMETIC AND DERMATOLOGICAL COMPOSITIONS FOR SHAVING THE SKIN | Maggesi, Luigi (IT) | 1984-07-04 | — | — | EP | claimed |
| EP-0034126-A1 | Cosmetic and dermatological compositions for shaving the skin | Maggesi, Luigi (IT) | 1981-08-19 | — | — | EP | claimed |
| CN-118696113-A | Foaming acidic hard surface cleaning compositions | 联合利华知识产权控股有限公司 | 2024-09-24 | — | — | CN | disclosed |
| EP-2492301-B1 | NOVEL CO-MODIFIED ORGANOPOLYSILOXANE | DOW TORAY CO LTD (JP) | 2023-03-29 | — | — | EP | disclosed |
| EP-2492300-B1 | NOVEL ORGANOPOLYSILOXANE COPOLYMER | DOW CORNING TORAY CO LTD (JP) | 2018-10-03 | — | — | EP | disclosed |
| US-9975999-B2 | Liquid organopolysiloxane and uses thereof | DOW CORNING TORAY CO., LTD. (JP) | 2018-05-22 | — | — | US | disclosed |
| US-9580600-B2 | Thickening or gelling agent for oily raw materials | DOW CONRING TORAY CO., LTD. (JP) | 2017-02-28 | — | — | US | disclosed |
| US-9133309-B2 | Organopolysiloxane copolymer | DOW CORNING TORAY CO., LTD. (JP) | 2015-09-15 | — | — | US | disclosed |
| US-20140364394-A1 | Novel Liquid Organopolysiloxane And Uses Thereof | DOW TORAY CO., LTD. (JP) | 2014-12-11 | — | — | US | disclosed |
| EP-2797991-A1 | NOVEL LIQUID ORGANOPOLYSILOXANE AND USES THEREOF | Dow Corning Toray Co., Ltd. (JP) | 2014-11-05 | — | — | EP | disclosed |
| US-8784787-B2 | Co-modified organopolysiloxane | DOW CORNING TORAY CO., LTD. (JP) | 2014-07-22 | — | — | US | disclosed |
| US-20120269748-A1 | Thickening Or Gelling Agent For Oily Raw Materials | DOW TORAY CO., LTD. (JP) | 2012-10-25 | — | — | US | disclosed |
| US-20120269875-A1 | Novel Co-Modified Organopolysiloxane | DOW TORAY CO., LTD. (JP) | 2012-10-25 | — | — | US | disclosed |
| US-20120269747-A1 | Novel Organopolysiloxane Copolymer | DOW TORAY CO., LTD. (JP) | 2012-10-25 | — | — | US | disclosed |
| EP-2492333-A1 | THICKENING OR GELLING AGENT FOR OILY RAW MATERIALS | Dow Corning Toray Co., Ltd. (JP) | 2012-08-29 | — | — | EP | disclosed |
| EP-2492300-A1 | NOVEL ORGANOPOLYSILOXANE COPOLYMER | Dow Corning Toray Co., Ltd. (JP) | 2012-08-29 | — | — | EP | disclosed |
| EP-2492301-A1 | NOVEL CO-MODIFIED ORGANOPOLYSILOXANE | Dow Corning Toray Co., Ltd. (JP) | 2012-08-29 | — | — | EP | disclosed |
| US-20010044393-A1 | Rinse-off antimicrobial liquid cleansing composition | LONZA INC. | 2001-11-22 | — | — | US | disclosed |
| US-4474912-A | Stable water-in-oil emulsions containing polyoxyalkylene block copolymers | BASF WYANDOTTE CORPORATION (US) | 1984-10-02 | — | — | US | disclosed |
| US-3934002-A | BIS-GUANIDE | THE PROCTER & GAMBLE COMPANY (US) | 1976-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010044393-A1 | Rinse-off antimicrobial liquid cleansing composition | ARG1, PARG, PUF60 | CHRM2 2377/4885CHRM1 1641/4885CHRM3 2640/4885 |
| US-20120269748-A1 | Thickening Or Gelling Agent For Oily Raw Materials | CUTA, PLOD3, FSCN1 | CHRM2 905/4885CHRM1 1090/4885CHRM3 1121/4885 |
| US-20140364394-A1 | Novel Liquid Organopolysiloxane And Uses Thereof | ALG1, SGMS1, LOXL1 | CHRM2 3436/4885CHRM1 3867/4885CHRM3 2234/4885 |
| US-20120269747-A1 | Novel Organopolysiloxane Copolymer | FUCA1, DDOST, ALG8 | CHRM2 957/4885CHRM1 1122/4885CHRM3 814/4885 |
| US-20120269875-A1 | Novel Co-Modified Organopolysiloxane | IDUA, HPSE, DDOST | CHRM2 2070/4885CHRM1 3228/4885CHRM3 2553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.