Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.69 |
| ▸ | ACMSD | Q8TDX5 | 3/20 | 0.59 |
| ▸ | HNF4A | P41235 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | DHFR | P00374 | 1/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.53 |
| ▸ | KMO | O15229 | 1/20 | 0.53 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.53 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.53 |
| ▸ | ERN1 | O75460 | 1/20 | 0.53 |
| ▸ | RXRA | P19793 | 2/20 | 0.51 |
| ▸ | RXRB | P28702 | 2/20 | 0.51 |
| ▸ | RXRG | P48443 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28397372 | 0.87 | MAP4K4 (0.59) | EGFRMAP4K4KMOTRIM24TRIM33 | |
| SCHEMBL3663963 | 0.86 | POLB (0.59) | EGFRKDM4EHSD17B10ALOX5KMO | |
| SCHEMBL1005885 | 0.86 | ALOX5 (0.70) | EGFRACMSDHNF4AKDM4ELMNA | |
| SCHEMBL3238016 | 0.84 | CA12 (0.61) | EGFRKDM4ELMNAHSD17B10ERN1 | |
| SCHEMBL4620446 | 0.84 | MAP4K4 (0.56) | EGFRLMNAMAP4K4KMOTRIM24 | |
| SCHEMBL29876739 | 0.82 | HSD17B10 (0.64) | EGFRKDM4ELMNAHSD17B10RXRA | |
| SCHEMBL2038730 | 0.82 | HSD17B10 (0.64) | EGFRKDM4ELMNAHSD17B10RXRA | |
| 2-Phenylphenol SCHEMBL9013767 | 0.82 | ALDH1A1 (0.71) | EGFRHNF4AHSD17B10MAP4K4ALOX5 | |
| SCHEMBL2346605 | 0.82 | KMO (0.76) | EGFRACMSDKMOTRIM24TRIM33 | |
| SCHEMBL17014850 | 0.82 | EGFR (0.62) | EGFRMAP4K4KMOTRIM24TRIM33 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952974-B1 | BIPHENYL DERIVATIVES SUBSTITUTED BY AN AROMATIC OR HETEROAROMATIC RADICAL AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME | GALDERMA RES & DEV (FR) | 2001-11-21 | — | — | EP | disclosed |