SCHEMBL7791694

SCHEMBL7791694

COC(=O)Nc1ccccc1-c1ccc(CBr)cc1

nearest known ligand 0.51

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CHRM3 P20309 9/20 0.45
LMNA P02545 4/20 0.45
GAA P10253 2/20 0.45
MEN1 O00255 2/20 0.45
KMT2A Q03164 2/20 0.45
L3MBTL1 Q9Y468 2/20 0.45
ALDH1A1 P00352 8/20 0.45
HTT P42858 3/20 0.45
MAPT P10636 3/20 0.45
KDM4E B2RXH2 2/20 0.45
MAPK1 P28482 1/20 0.44
NPY1R P25929 1/20 0.43
NPY2R P49146 1/20 0.43
CHRM2 P08172 1/20 0.42
CHRM1 P11229 1/20 0.42
PLA2G1B P04054 1/20 0.42
ATG4B Q9Y4P1 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7785749 0.88 CHRM3 (0.48) CHRM3LMNAGAAMEN1KMT2A
SCHEMBL8904461 0.83 LMNA (0.43) CHRM3LMNAGAAMEN1KMT2A
SCHEMBL2092774 0.82 ALDH1A1 (0.57) CHRM3LMNAMEN1KMT2AL3MBTL1
SCHEMBL11662901 0.81 SMN1; SMN2 (0.54) CHRM3LMNAMEN1KMT2AALDH1A1
SCHEMBL7794460 0.81 FABP4 (0.48) LMNAGAAMEN1KMT2AL3MBTL1
SCHEMBL11657197 0.79 HPGD (0.53) CHRM3LMNAMEN1KMT2AL3MBTL1
SCHEMBL23360743 0.77 CHRM3 (0.46) CHRM3LMNAMEN1KMT2AL3MBTL1
SCHEMBL562 0.76 SLC6A3 (0.68) LMNAKMT2AHTT
SCHEMBL29390423 0.76 SLC6A3 (0.68) LMNAKMT2AHTT
SCHEMBL8670912 0.75 SLC6A3 (0.66) KMT2AHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0659179-B1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO INC (US) 2001-11-21 EP disclosed
US-5968924-A HAVE THE ABILITY TO STIMULATE THE RELEASE OF NATURAL OR ENDOGENOUS GROWTH HORMONE; TREATMENT OF OBESITY, OSTEOPOROSIS MERCK & CO., INC. (US) 1999-10-19 US disclosed
US-5672596-A ANIMAL GROWTH CONTROLLERS MERCK & CO., INC. (US) 1997-09-30 US disclosed
EP-0711287-A4 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO INC (US) 1996-08-28 EP disclosed
EP-0711287-A1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO. INC. (US) 1996-05-15 EP disclosed
EP-0659179-A4 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE. MERCK & CO INC (US) 1995-08-09 EP disclosed
US-5430144-A E.g, N-(1-((2'-((methoxycarbonyl)amino)(1,1'-biphenyl)-4-yl) methyl)-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl)-3 ((fur-2-yl)methyl)amino-3-methylbutanamide MERCK & CO., INC. (US) 1995-07-04 US disclosed
EP-0659179-A1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO. INC. (US) 1995-06-28 EP disclosed
WO-1995003290-A1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO., INC. (US) 1995-02-02 WO disclosed
WO-1994005634-A1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO., INC. (US) 1994-03-17 WO disclosed
US-5283241-A Animal growth regulators MERCK & CO., INC. (US) 1994-02-01 US disclosed