Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 3/20 | 0.37 |
| ▸ | CTSL | P07711 | 2/20 | 0.37 |
| ▸ | CTSS | P25774 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 2/20 | 0.35 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.35 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.35 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.35 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.35 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.35 |
| ▸ | PSMD3 | O43242 | 1/20 | 0.35 |
| ▸ | PSMC3 | P17980 | 1/20 | 0.35 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7799736 | 0.89 | L3MBTL1 (0.40) | NPC1CTSBCTSSMEN1KMT2A | |
| SCHEMBL7135455 | 0.83 | CTSB (0.38) | CTSBCTSLCTSSMEN1LMNA | |
| SCHEMBL20147826 | 0.82 | ALDH1A1 (0.50) | CTSBCTSLCTSSLMNAKMT2A | |
| SCHEMBL6182061 | 0.81 | CTSS (0.54) | CTSBCTSLCTSSCTSK | |
| SCHEMBL7136764 | 0.73 | SMN1; SMN2 (0.42) | CTSBCTSLSMN1; SMN2CTSK | |
| SCHEMBL8708277 | 0.72 | MMP3 (0.50) | LMNAALDH1A1 | |
| SCHEMBL6182057 | 0.72 | CTSL (0.47) | CTSBCTSLCTSSABCB1ALDH1A1 | |
| SCHEMBL7130342 | 0.72 | CTSB (0.41) | NPC1CTSBCTSLCTSSMEN1 | |
| Hydrochloric Acid SCHEMBL7543462 | 0.71 | NPC1 (0.51) | NPC1KMT2ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL6406671 | 0.71 | AR (0.45) | NPC1CTSLCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1159260-A1 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000055124-A2 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |