Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 2/20 | 0.31 |
| ▸ | CTSG | P08311 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.30 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7817046 | 0.81 | POLB (0.33) | KDM4E | |
| SCHEMBL7816658 | 0.76 | CRHR1 (0.32) | CRHR1 | |
| SCHEMBL7814352 | 0.66 | HCAR1 (0.34) | — | |
| SCHEMBL7813650 | 0.66 | CYP11B2 (0.31) | — | |
| SCHEMBL30098086 | 0.60 | CNR2 (0.35) | ELANECTSG | |
| SCHEMBL21815186 | 0.58 | SMN1; SMN2 (0.51) | — | |
| SCHEMBL20467095 | 0.57 | ALOX5 (0.41) | ELANE | |
| SCHEMBL19003636 | 0.56 | ERBB2 (0.44) | ERBB2 | |
| SCHEMBL20014473 | 0.56 | OXER1 (0.47) | — | |
| SCHEMBL21230758 | 0.56 | ALOX5 (0.40) | ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091941-A1 | NOVEL BENZIMIDAZOLES AS CORTICOTROPIN RELEASE FACTOR ANTAGONISTS | Du Pont Pharmaceuticals Company (US) | 2001-04-18 | — | — | EP | claimed |
| WO-2000001675-A1 | NOVEL BENZIMIDAZOLES AS CORTICOTROPIN RELEASE FACTOR ANTAGONISTS | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-01-13 | — | — | WO | claimed |