Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7809185 | 0.87 | TDP1 (0.41) | TDP1ALDH1A1 | |
| SCHEMBL7805486 | 0.87 | P2RX4 (0.41) | ALDH1A1MMP9NPSR1P2RX4TP53 | |
| SCHEMBL7809186 | 0.86 | CASP3 (0.40) | POLBAPEX1HSD17B10TDP1CASP3 | |
| SCHEMBL7805571 | 0.86 | KIF11 (0.40) | NPC1ALDH1A1MMP9NPSR1P2RX4 | |
| Acetic Acid SCHEMBL7809331 | 0.84 | ALDH1A1 (0.39) | ALDH1A1MMP9NPSR1P2RX4TP53 | |
| SCHEMBL7805553 | 0.83 | CASP3 (0.43) | POLBAPEX1HSD17B10TDP1CASP3 | |
| SCHEMBL7809176 | 0.83 | HCRTR2 (0.41) | ALDH1A1MMP2MMP9NPSR1P2RX4 | |
| SCHEMBL7811618 | 0.81 | ALDH1A1 (0.42) | POLBALDH1A1MMP2MMP9NPSR1 | |
| SCHEMBL7805536 | 0.79 | CA1 (0.43) | ALDH1A1MMP2MMP9NPSR1TP53 | |
| SCHEMBL7800320 | 0.79 | MMP1 (0.38) | POLBALDH1A1MMP2MMP9NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528678-B1 | A pyrrolidylthiocarbapenem derivative with antibacterial activity | SHIONOGI & CO (JP) | 2001-05-23 | — | — | EP | disclosed |
| US-5703243-A | Intermediates for pyrrolidylthiocarbapenem derivative | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1997-12-30 | — | — | US | disclosed |
| US-5317016-A | Pyrrolidylthiocarbapenem derivative | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1994-05-31 | — | — | US | disclosed |
| EP-0528678-A1 | A pyrrolidylthiocarbapenem derivative | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1993-02-24 | — | — | EP | disclosed |