Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OXTR | P30559 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 4/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78179 | 0.80 | KDM4E (0.43) | RAB9APOLBKDM4EL3MBTL1KMT2A | |
| SCHEMBL78926 | 0.80 | MAPT (0.38) | RAB9APOLBKDM4ERXRAGRIN1 | |
| SCHEMBL10289207 | 0.80 | OXTR (0.35) | OXTRPOLBKDM4ERXRAGRIN1 | |
| SCHEMBL78506 | 0.79 | L3MBTL1 (0.44) | RAB9APOLBKDM4EL3MBTL1KMT2A | |
| SCHEMBL78925 | 0.77 | L3MBTL1 (0.45) | RAB9APOLBKDM4EL3MBTL1LMNA | |
| SCHEMBL13165244 | 0.75 | KDM4E (0.41) | RAB9APOLBKDM4EL3MBTL1KMT2A | |
| SCHEMBL78449 | 0.74 | SCN8A (0.40) | RAB9APOLBKDM4EKMT2ALMNA | |
| SCHEMBL78167 | 0.73 | KMT2A (0.54) | RAB9AL3MBTL1KMT2ALMNATSHR | |
| SCHEMBL12109478 | 0.73 | ACACB (0.47) | RAB9APOLBKDM4EL3MBTL1KMT2A | |
| SCHEMBL78505 | 0.72 | KDM4E (0.41) | RAB9APOLBKDM4EL3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |