Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78179 | 0.91 | KDM4E (0.43) | KDM4ELMNAPOLBRAB9AHRH3 | |
| SCHEMBL91291 | 0.81 | LMNA (0.41) | KDM4ELMNAPOLBHRH3L3MBTL1 | |
| SCHEMBL78180 | 0.80 | KDM4E (0.46) | KDM4ELMNAPOLBRAB9AHRH3 | |
| SCHEMBL5282486 | 0.78 | KDM4E (0.53) | KDM4ELMNAPOLBRAB9AHRH3 | |
| SCHEMBL78168 | 0.75 | L3MBTL1 (0.46) | KDM4ELMNAPOLBRAB9AHRH3 | |
| SCHEMBL28222875 | 0.74 | HTT (0.40) | LMNAPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL78164 | 0.72 | OXTR (0.34) | KDM4ELMNAPOLBRAB9AATM | |
| SCHEMBL91267 | 0.72 | LMNA (0.43) | KDM4ELMNAPOLBRAB9AHRH3 | |
| SCHEMBL1535645 | 0.71 | KDM4E (0.53) | KDM4ELMNAPOLBRAB9AHRH3 | |
| SCHEMBL22248702 | 0.70 | HRH3 (0.62) | KDM4ELMNAPOLBRAB9AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |