Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 3/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7811843 | 0.97 | ADRA1B (0.41) | ADRA1DADRA1AADRA1BMEN1KMT2A | |
| SCHEMBL8639466 | 0.74 | SIGMAR1 (0.53) | DRD2DRD4SIGMAR1 | |
| SCHEMBL9041264 | 0.73 | SIGMAR1 (0.50) | DRD2DRD4SIGMAR1 | |
| SCHEMBL7811838 | 0.73 | HTR2C (0.48) | — | |
| SCHEMBL7805133 | 0.73 | DRD2 (0.55) | ADRA1DADRA1AADRA1BHTR1ASLC6A4 | |
| SCHEMBL7805210 | 0.73 | ADRA1D (0.45) | ADRA1DADRA1AADRA1BHTR1ASLC6A4 | |
| SCHEMBL7828721 | 0.72 | HTR6 (0.48) | ADRA1DADRA1AADRA1BHTR1ASLC6A4 | |
| SCHEMBL7805201 | 0.71 | HTR2C (0.43) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL7812155 | 0.71 | DRD2 (0.49) | ADRA1DADRA1AADRA1BMEN1KMT2A | |
| SCHEMBL9041270 | 0.70 | ADRA1D (0.41) | ADRA1DADRA1AADRA1BHTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745598-B1 | Piperazine, piperidine and 1,2,5,6-tetrahydropyridine derivatives, proces for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-08-22 | — | — | EP | disclosed |
| EP-0745598-A1 | Piperazine, piperidine and 1,2,5,6-tetrahydropyridine derivatives, proces for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-12-04 | — | — | EP | disclosed |