Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 4/20 | 0.51 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7828179 | 0.92 | AKR1C3 (0.53) | AKR1C3PTGDR2MEN1KMT2AALDH1A1 | |
| SCHEMBL7824961 | 0.88 | CYP19A1 (0.46) | AKR1C3LMNACYP19A1ALDH1A1MAPT | |
| SCHEMBL8073566 | 0.84 | CASP3 (0.44) | AKR1C3LMNACYP19A1MEN1KMT2A | |
| SCHEMBL8073356 | 0.81 | AKR1C3 (0.47) | AKR1C3LMNACYP19A1MEN1KMT2A | |
| SCHEMBL8057396 | 0.79 | CYP19A1 (0.45) | AKR1C3LMNACYP19A1MEN1KMT2A | |
| SCHEMBL7828177 | 0.79 | AKR1C3 (0.47) | AKR1C3MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7830775 | 0.78 | UCHL1 (0.53) | AKR1C3LMNACYP19A1MEN1KMT2A | |
| SCHEMBL5517220 | 0.78 | UCHL1 (0.55) | LMNACYP19A1MEN1KMT2AALDH1A1 | |
| SCHEMBL7829631 | 0.78 | AKR1C3 (0.51) | AKR1C3CYP19A1MEN1KMT2AALDH1A1 | |
| SCHEMBL7829087 | 0.77 | POLB (0.48) | AKR1C3CYP19A1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686636-B1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA CO (JP) | 2001-04-04 | — | — | EP | disclosed |
| EP-0686636-A1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1995-12-13 | — | — | EP | disclosed |