Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7831499 | 0.87 | HDAC1 (0.51) | ALOX5HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7596070 | 0.85 | SMN1; SMN2 (0.58) | SMN1; SMN2ALOX15HTTHPGDPOLB | |
| SCHEMBL7832126 | 0.85 | L3MBTL1 (0.48) | SMN1; SMN2HTTPOLBHSD17B10ALDH1A1 | |
| SCHEMBL28712690 | 0.81 | SMN1; SMN2 (0.54) | SMN1; SMN2ALOX15HTTHPGDPOLB | |
| SCHEMBL11514240 | 0.75 | MAPK9 (0.52) | SMN1; SMN2HTTHPGDHSD17B10ALDH1A1 | |
| SCHEMBL28337548 | 0.74 | MAPK9 (0.51) | SMN1; SMN2HPGDHSD17B10ALDH1A1CYP1A2 | |
| SCHEMBL5256102 | 0.73 | LOXL2 (0.60) | SMN1; SMN2ALOX15HTTHPGDPOLB | |
| SCHEMBL7835431 | 0.71 | SMN1; SMN2 (0.89) | SMN1; SMN2ALOX15HTTHPGDPOLB | |
| SCHEMBL7835167 | 0.71 | SMN1; SMN2 (0.89) | SMN1; SMN2ALOX15HTTHPGDPOLB | |
| SCHEMBL9179542 | 0.71 | POLB (0.56) | SMN1; SMN2ALOX15HTTHPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0737671-B1 | Aromatic hydroxamic acid compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-12-12 | — | — | EP | disclosed |
| US-5804601-A | USEFUL FOR TREATING ALZHEIMER'S DISEASE, MULTIPLE SCLEROSIS, BACTERIAL OR VIRAL MENINGITIS, DOWN'S SYNDROME AND PARKINSON'S DISEASE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-09-08 | — | — | US | disclosed |
| EP-0737671-A2 | Aromatic hydroxamic acid compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1996-10-16 | — | — | EP | disclosed |