Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL65202 | 0.87 | MGLL (0.36) | PDK1PDK2PDK3PDK4NPSR1 | |
| SCHEMBL78635 | 0.87 | PDK1 (0.35) | PDK1PDK2PDK3PDK4NPSR1 | |
| SCHEMBL65231 | 0.84 | CHRM5 (0.39) | PDK1PDK2PDK3PDK4NPSR1 | |
| SCHEMBL80037 | 0.83 | ITGB3 (0.32) | — | |
| SCHEMBL78866 | 0.82 | PPARG (0.36) | — | |
| SCHEMBL8701755 | 0.78 | PSEN1 (0.41) | PDK1PDK2PDK3PDK4NPSR1 | |
| SCHEMBL8701756 | 0.78 | PSEN1 (0.41) | PDK1PDK2PDK3PDK4NPSR1 | |
| SCHEMBL64061 | 0.77 | CHRM2 (0.38) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL7576828 | 0.77 | PDK1 (0.40) | PDK1PDK2PDK3PDK4NPSR1 | |
| SCHEMBL78404 | 0.76 | PDK1 (0.35) | PDK1PDK2PDK3PDK4NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |