Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 8/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6178084 | 0.72 | TDP1 (0.41) | HCAR3TDP1POLBGAAMAPT | |
| SCHEMBL9651421 | 0.66 | HCAR3 (0.39) | HCAR3TDP1POLBGAAMAPT | |
| SCHEMBL17512440 | 0.64 | HCAR3 (0.62) | HCAR3TSHRCASP6KMT2A | |
| SCHEMBL425321 | 0.64 | CASP6 (0.60) | HCAR3POLBTSHRCASP6 | |
| SCHEMBL3262597 | 0.63 | HCAR3 (0.41) | HCAR3TDP1POLBCASP6ALDH1A1 | |
| SCHEMBL11625787 | 0.63 | RXRA (0.47) | HCAR3TDP1GAAMAPTTSHR | |
| SCHEMBL9650922 | 0.62 | GPR35 (0.40) | HCAR3GAAMAPTTSHRCASP6 | |
| SCHEMBL22119164 | 0.62 | SMN1; SMN2 (0.44) | HCAR3POLBGAAALDH1A1KMT2A | |
| SCHEMBL28534811 | 0.62 | SMN1; SMN2 (0.64) | TDP1POLBGAAMAPTALDH1A1 | |
| SCHEMBL7645214 | 0.62 | GABRA1 (0.41) | HCAR3TDP1POLBMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163236-A1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000055152-A1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |