Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 5/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 5/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.34 |
| ▸ | INCENP | Q9NQS7 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KLK7 | P49862 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7840409 | 0.81 | SSTR4 (0.42) | ELANEOPRM1KMT2ALMNAHPGD | |
| SCHEMBL7845340 | 0.72 | OPRD1 (0.46) | OPRM1KMT2ALMNAHPGDSMN1; SMN2 | |
| SCHEMBL7839338 | 0.71 | CACNA1F (0.44) | KMT2ALMNASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL13278538 | 0.70 | POLB (0.53) | OPRM1KMT2ALMNAMEN1ALDH1A1 | |
| SCHEMBL22366449 | 0.67 | L3MBTL1 (0.47) | LMNAHPGDSMN1; SMN2L3MBTL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7842057 | 0.67 | SYK (0.35) | OPRM1SYKAURKBINCENPKMT2A | |
| SCHEMBL7838387 | 0.65 | PKM (0.44) | KMT2ALMNAMEN1ALDH1A1MAPT | |
| SCHEMBL23189019 | 0.65 | TSHR (0.50) | KMT2ALMNAHPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL13278434 | 0.63 | ALDH1A1 (0.55) | OPRM1KMT2ALMNAMEN1ALDH1A1 | |
| SCHEMBL13278520 | 0.63 | OPRM1 (0.51) | OPRM1KMT2ALMNASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944388-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-16 | — | — | EP | disclosed |
| EP-0944388-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1997038665-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | disclosed |