Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.57 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 2/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.49 |
| ▸ | TAS2R14 | Q9NYV8 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL984791 | 0.79 | TAS2R14 (0.71) | HSD11B1ALDH1A1CNR2TAS2R14MEN1 | |
| SCHEMBL28308667 | 0.79 | SERPINE1 (0.64) | APOBEC3GHSD11B1ALDH1A1SMN1; SMN2CNR2 | |
| SCHEMBL17333377 | 0.78 | APOBEC3G (0.59) | APOBEC3GHSD11B1ALDH1A1SMN1; SMN2CNR2 | |
| SCHEMBL4755722 | 0.78 | CA2 (0.64) | ALDH1A1CA2 | |
| SCHEMBL407669 | 0.76 | ALDH1A1 (0.73) | ALDH1A1MEN1KMT2AL3MBTL1LMNA | |
| SCHEMBL5966695 | 0.76 | HSD11B1 (0.53) | APOBEC3GHSD11B1ALDH1A1SMN1; SMN2CNR2 | |
| SCHEMBL3555916 | 0.74 | TDP1 (0.58) | APOBEC3GSMN1; SMN2MEN1KMT2AESR1 | |
| SCHEMBL5330652 | 0.74 | ESR1 (0.78) | ALDH1A1SMN1; SMN2CNR2NR3C1MEN1 | |
| SCHEMBL17493156 | 0.74 | KEAP1 (0.56) | APOBEC3GHSD11B1ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL27731679 | 0.74 | APOBEC3G (0.61) | APOBEC3GHSD11B1ALDH1A1SMN1; SMN2TAS2R14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160280718-A1 | NOVEL ANTIBACTERIAL AGENTS | MERCK SHARP & DOHME (US) | 2016-09-29 | — | — | US | disclosed |
| US-9200026-B2 | Antibacterial agents | MERCK SHARP & DOHME CORP. (US) | 2015-12-01 | — | — | US | disclosed |
| US-8343936-B2 | Antibacterial agents | OPTIMER PHARMACEUTICALS, INC. (US) | 2013-01-01 | — | — | US | disclosed |
| US-20120071429-A1 | Novel antibacterial agents | TETARD, INC. | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160280718-A1 | NOVEL ANTIBACTERIAL AGENTS | MRPL21, MRPL12, CTSA | APOBEC3G 4707/4885HSD11B1 2909/4885ALDH1A1 4735/4885 |
| US-20120071429-A1 | Novel antibacterial agents | MRPL21, CTSA, MRPL12 | APOBEC3G 4629/4885HSD11B1 2762/4885ALDH1A1 4594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.