Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | REN | P00797 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | P4HB | P07237 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL91281 | 0.90 | L3MBTL1 (0.43) | GPR84L3MBTL1KDM4EALDH1A1BACE1 | |
| SCHEMBL662701 | 0.84 | TSHR (0.39) | ALDH1A1RENKCNH2HPGDTSHR | |
| SCHEMBL8251205 | 0.82 | HTR1A (0.44) | L3MBTL1ALDH1A1TSHRHTR2ASMN1; SMN2 | |
| SCHEMBL660708 | 0.81 | SLC6A4 (0.47) | KCNH2TSHRHTR2ASLC6A4SIGMAR1 | |
| SCHEMBL16771200 | 0.81 | PNMT (0.55) | ALDH1A1KCNH2HPGDTSHRPNMT | |
| SCHEMBL3790563 | 0.78 | TRPA1 (0.43) | GPR84L3MBTL1KDM4EALDH1A1BACE1 | |
| SCHEMBL664960 | 0.78 | MRGPRX4 (0.50) | KDM4EALDH1A1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL8037422 | 0.78 | GPR84 (0.41) | GPR84KDM4EALDH1A1KCNH2HPGD | |
| SCHEMBL44646 | 0.78 | BACE1 (0.62) | KDM4EALDH1A1BACE1HTR2APNMT | |
| SCHEMBL667234 | 0.78 | NR3C1 (0.43) | L3MBTL1KDM4EALDH1A1RENKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |