Biphenyl

Biphenyl

SCHEMBL7865199

O.P.c1ccc(-c2ccccc2)cc1

nearest known ligand 0.82

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A4 known ✓ P31645 1/20 0.47
ALOX5 known ✓ P09917 1/20 0.43
ALDH1A1 P00352 2/20 0.82
MAPK1 P28482 2/20 0.53
TAAR1 Q96RJ0 2/20 0.53
CYP1A2 P05177 1/20 0.53
CYP3A4 P08684 1/20 0.53
HSD17B10 Q99714 1/20 0.53
TDP1 Q9NUW8 1/20 0.53
NOTUM Q6P988 1/20 0.53
MMP3 P08254 1/20 0.53
BCL2L1 Q07817 1/20 0.53
ATM Q13315 1/20 0.47
SLC22A2 O15244 1/20 0.47
SLC22A1 O15245 1/20 0.47
SLC22A3 O75751 1/20 0.47
NPC1 O15118 2/20 0.47
RAB9A P51151 2/20 0.47
MAOA P21397 1/20 0.45
NFKB1 P19838 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Biphenyl SCHEMBL28814327 1.00 ALDH1A1 (0.82) ALDH1A1MAPK1TAAR1CYP1A2CYP3A4
Biphenyl SCHEMBL27966871 0.95 ALDH1A1 (0.90) ALDH1A1MAPK1TAAR1CYP1A2CYP3A4
Biphenyl SCHEMBL3694239 0.95 ALDH1A1 (0.90) ALDH1A1MAPK1TAAR1CYP1A2CYP3A4
Biphenyl SCHEMBL27907683 0.95 ALDH1A1 (0.90) ALDH1A1MAPK1TAAR1CYP1A2CYP3A4
Biphenyl SCHEMBL11354282 0.95 ALDH1A1 (0.90) ALDH1A1MAPK1TAAR1CYP1A2CYP3A4
Biphenyl SCHEMBL27842187 0.95 ALDH1A1 (0.90) ALDH1A1MAPK1TAAR1CYP1A2CYP3A4
Biphenyl SCHEMBL51203 0.95 ALDH1A1 (0.90) ALDH1A1MAPK1TAAR1CYP1A2CYP3A4
Biphenyl SCHEMBL128558 0.95 ALDH1A1 (0.90) ALDH1A1MAPK1TAAR1CYP1A2CYP3A4
Biphenyl SCHEMBL9579759 0.95 ALDH1A1 (0.90) ALDH1A1MAPK1TAAR1CYP1A2CYP3A4
Biphenyl SCHEMBL8993020 0.95 ALDH1A1 (0.90) ALDH1A1MAPK1TAAR1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119522247-A Polycarbonate-polyorganosiloxane copolymer, polycarbonate resin composition, and molded article 出光兴产株式会社 2025-02-25 CN disclosed
CN-119343393-A Polycarbonate-polyorgano Silicone copolymer 出光兴产株式会社 2025-01-21 CN disclosed
CN-114746474-B Polycarbonate-polyorganosiloxane copolymer and resin composition containing the same 出光兴产株式会社 2024-11-22 CN disclosed
CN-114746473-B Polycarbonate-polyorganosiloxane copolymer and resin composition containing the same 出光兴产株式会社 2024-11-15 CN disclosed
CN-117500882-A Polycarbonate resin composition and molded article 出光兴产株式会社 2024-02-02 CN disclosed
CN-117480217-A Polycarbonate resin composition and molded article 出光兴产株式会社 2024-01-30 CN disclosed
CN-117460785-A Polycarbonate resin composition and molded article 出光兴产株式会社 2024-01-26 CN disclosed
CN-117460784-A Polycarbonate resin composition and molded article 出光兴产株式会社 2024-01-26 CN disclosed
CN-117460786-A Polycarbonate resin composition and molded article 出光兴产株式会社 2024-01-26 CN disclosed
CN-117440988-A Polycarbonate resin composition and molded article 出光兴产株式会社 2024-01-23 CN disclosed
CN-101412805-B Catalyst for polymerization of polyester, polyester and process for preparing polyester TOYO BOSEKI 2011-10-19 CN disclosed
CN-101208371-B Method for preparing polyester and polyester manufactured by the method as well as polyester formed body TOYO BOSEKI 2011-08-10 CN disclosed
CN-101412805-A Catalyst for polymerization of polyester, polyester and process for preparing polyester TOYO BOSEKI (JP) 2009-04-22 CN disclosed
CN-100480300-C Polyester polymerization catalyst, polyester and process for producing polyester TOYO BOSEKI (JP) 2009-04-22 CN disclosed
CN-101263175-A Polyester, process for production of polyester, and polyester molded article TOYO BOSEKI (JP) 2008-09-10 CN disclosed
CN-101208371-A Method for preparing polyester and polyester manufactured by the method as well as polyester formed body TOYO BOSEKI (JP) 2008-06-25 CN disclosed
CN-1486336-A Polyester polymerization catalyst, polyester and process for producing polyester 东洋纺织株式会社 2004-03-31 CN disclosed
CN-1295590-A Polycarbonate and optical material IDEMITSU PETROCHEMICAL CO (JP) 2001-05-16 CN disclosed
EP-1069146-A1 POLYCARBONATE AND OPTICAL MATERIAL Idemitsu Petrochemical Co., Ltd. (JP) 2001-01-17 EP disclosed
EP-1035150-A1 COPOLYCARBONATE AND PROCESS FOR PRODUCING THE SAME IDEMITSU PETROCHEMICAL CO., LTD. (JP) 2000-09-13 EP disclosed