Sugi Predict

Sugi Predict / Compounds / SCHEMBL7865689

SCHEMBL7865689

SCHEMBL7865689

Cc1ccc2c(c1)CCCNC2

nearest known ligand 0.67

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ ASIC3 Q9UHC3 2/20 0.47
▸ DRD2 P14416 1/20 0.44
▸ DRD3 P35462 1/20 0.44
▸ PNMT P11086 5/20 0.43
▸ CD44 P16070 1/20 0.41
▸ MAOB P27338 1/20 0.41
▸ HTR6 P50406 1/20 0.40
▸ CD274 Q9NZQ7 1/20 0.40
▸ PARP10 Q53GL7 2/20 0.40
▸ PARP11 Q9NR21 1/20 0.40
▸ PARP1 P09874 1/20 0.40
▸ ADRA2A P08913 1/20 0.39
▸ ADRA2B P18089 1/20 0.39
▸ ADRA2C P18825 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17813307 0.92 PNMT (0.47) DRD2DRD3PNMTADRA2AADRA2B
SCHEMBL1001109 0.88 ASIC3 (0.60) ASIC3DRD2DRD3PNMTCD44
SCHEMBL15957848 0.87 PNMT (0.46) DRD2DRD3PNMTADRA2AADRA2B
SCHEMBL3240344 0.80 PNMT (0.60) DRD2DRD3PNMTCD44MAOB
SCHEMBL29587394 0.80 PNMT (0.60) DRD2DRD3PNMTCD44MAOB
SCHEMBL30560114 0.79 CHRNB2 (0.41) ASIC3PNMTPARP10PARP11PARP1
SCHEMBL5068876 0.79 CHRNB2 (0.41) ASIC3PNMTPARP10PARP11PARP1
Hydrochloric Acid SCHEMBL29587818 0.78 PNMT (0.58) DRD2DRD3PNMTCD44MAOB
Hydrochloric Acid SCHEMBL21331206 0.78 PNMT (0.58) DRD2DRD3PNMTCD44MAOB
SCHEMBL14704881 0.78 ASIC3 (0.48) ASIC3DRD2DRD3PNMTCD44

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11332468-B2 Azaindole derivatives as Rho-kinase inhibitors CHIESI FARMACEUTICI S.P.A. (IT) 2022-05-17 — — US claimed
EP-3728248-B1 AZAINDOLE DERIVATIVES AS RHO-KINASE INHIBITORS CHIESI FARM SPA (IT) 2022-02-02 — — EP claimed
US-20200392133-A1 AZAINDOLE DERIVATIVES AS RHO- KINASE INHIBITORS CHIESI FARMACEUTICI S.P.A. (IT) 2020-12-17 — — US claimed
EP-3728248-A1 AZAINDOLE DERIVATIVES AS RHO-KINASE INHIBITORS Chiesi Farmaceutici S.p.A. (IT) 2020-10-28 — — EP claimed
US-11795165-B2 Tetrahydro-benzoazepine glycosidase inhibitors ASCENEURON SA (CH) 2023-10-24 — — US disclosed
US-11332468-B2 Azaindole derivatives as Rho-kinase inhibitors CHIESI FARMACEUTICI S.P.A. (IT) 2022-05-17 — — US disclosed
EP-3728248-B1 AZAINDOLE DERIVATIVES AS RHO-KINASE INHIBITORS CHIESI FARM SPA (IT) 2022-02-02 — — EP disclosed
EP-3728248-B1 AZAINDOLE DERIVATIVES AS RHO-KINASE INHIBITORS CHIESI FARM SPA (IT) 2022-02-02 — — EP disclosed
US-20220002278-A9 HISTONE ACETYLTRANSFERASE (HAT) INHIBITOR AND USE THEREOF SUZHOU INSTITUTE OF MATERIA MEDICA (CN) 2022-01-06 — — US disclosed
US-20210101891-A1 HISTONE ACETYLTRANSFERASE (HAT) INHIBITOR AND USE THEREOF SHANGHAI INST MATERIA MEDICA CAS (CN) 2021-04-08 — — US disclosed
US-20200392133-A1 AZAINDOLE DERIVATIVES AS RHO- KINASE INHIBITORS CHIESI FARMACEUTICI S.P.A. (IT) 2020-12-17 — — US disclosed
EP-3728248-A1 AZAINDOLE DERIVATIVES AS RHO-KINASE INHIBITORS Chiesi Farmaceutici S.p.A. (IT) 2020-10-28 — — EP disclosed
US-8796289-B2 Pyridazino[4,5-D]pyrimidin-5(6H)-one inhibitors of kinases ABBVIE INC. (US) 2014-08-05 — — US disclosed
US-8710065-B2 Tricyclic inhibitors of kinases ABBVIE INC. (US) 2014-04-29 — — US disclosed
WO-2013126656-A1 PYRIDOPYRIMIDINONE INHIBITORS OF KINASES ABBVIE INC. (US) 2013-08-29 — — WO disclosed
US-20130225589-A1 PYRIDOPYRIMIDINONE INHIBITORS OF KINASES ABBVIE INC. (US) 2013-08-29 — — US disclosed
US-20130102590-A1 PYRIDOPYRIMIDINONE INHIBITORS OF KINASES ABBVIE INC (US) 2013-04-25 — — US disclosed
WO-2013059485-A1 PYRIDOPYRIMIDINONE INHIBITORS OF KINASES ABBVIE INC. (US) 2013-04-25 — — WO disclosed
US-20110130385-A1 Bicyclic Heterocylic Derivatives and Methods of Use SCHERING CORPORATION 2011-06-02 — — US disclosed
WO-2010151318-A1 SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF MILLENNIUM PHARMACEUTICALS, INC. (US) 2010-12-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130102590-A1 PYRIDOPYRIMIDINONE INHIBITORS OF KINASES WEE1, WEE2, CDK1 ASIC3 2796/4885DRD2 4358/4885DRD3 4041/4885
US-11332468-B2 Azaindole derivatives as Rho-kinase inhibitors ROCK1, ROCK2, RHOA ASIC3 3819/4885DRD2 3580/4885DRD3 3542/4885
US-20130225589-A1 PYRIDOPYRIMIDINONE INHIBITORS OF KINASES WEE1, WEE2, CDK1 ASIC3 2796/4885DRD2 4358/4885DRD3 4041/4885
US-20210101891-A1 HISTONE ACETYLTRANSFERASE (HAT) INHIBITOR AND USE THEREOF EP300, HDAC11, HDAC1 ASIC3 4401/4885DRD2 4517/4885DRD3 4157/4885
US-20110130385-A1 Bicyclic Heterocylic Derivatives and Methods of Use GPR119, OXER1, INSR ASIC3 1209/4885DRD2 628/4885DRD3 617/4885
US-20200392133-A1 AZAINDOLE DERIVATIVES AS RHO- KINASE INHIBITORS ROCK1, ROCK2, RHOA ASIC3 3819/4885DRD2 3580/4885DRD3 3542/4885
US-20220002278-A9 HISTONE ACETYLTRANSFERASE (HAT) INHIBITOR AND USE THEREOF EP300, HDAC11, HDAC1 ASIC3 4401/4885DRD2 4517/4885DRD3 4157/4885
US-11795165-B2 Tetrahydro-benzoazepine glycosidase inhibitors BACE1, BACE2, BCHE ASIC3 2727/4885DRD2 1589/4885DRD3 1089/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.