SCHEMBL7868519

SCHEMBL7868519

CCC(CC)(C(=O)O)c1ccc(C#N)cc1

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 1/20 0.43
KIF11 P52732 2/20 0.43
CTBP2 P56545 1/20 0.42
CYP2A6 P11509 1/20 0.42
MGLL Q99685 2/20 0.41
CYP19A1 P11511 1/20 0.41
MLYCD O95822 1/20 0.41
GSK3B P49841 1/20 0.41
CA1 P00915 2/20 0.40
CA2 P00918 2/20 0.40
HTT P42858 1/20 0.40
PTPN5 P54829 1/20 0.39
ALDH1A1 P00352 1/20 0.39
MAPT P10636 1/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
MMP2 P08253 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9259276 0.82 GSK3B (0.44) EPHX2KIF11CTBP2CYP2A6CYP19A1
SCHEMBL7412854 0.79 MEN1 (0.63) EPHX2KIF11CTBP2CYP2A6CYP19A1
SCHEMBL3792532 0.77 NPC1 (0.43) KIF11CTBP2ALDH1A1MAPTMEN1
SCHEMBL28692951 0.77 ESR1 (0.54) ALDH1A1MEN1KMT2A
SCHEMBL504013 0.77 ALDH1A1 (0.57) KIF11HTTALDH1A1MAPTKMT2A
SCHEMBL25170199 0.76 RXRA (0.37)
SCHEMBL11039437 0.76 CYP1A2 (0.44) EPHX2ALDH1A1MAPTMEN1KMT2A
SCHEMBL8224210 0.76 KIF11 (0.52) EPHX2KIF11CYP2A6GSK3BCA1
SCHEMBL2535031 0.76 MIF (0.50) CYP19A1HTTALDH1A1MAPTMEN1
SCHEMBL3355856 0.76 CES2 (0.47) EPHX2GSK3BHTTALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6326500-B1 ANTIINFLAMMATORY AGENTS; ANTIALLERGENS ABBOTT LABORATORIES 2001-12-04 US disclosed
US-6215001-B1 ANTIINFLAMMATORY AGENTS, ANTIASTHMATICS, AND ANTIALLERGENS; SIDE EFFECT REDUCTION KNOLL AKTIENGESELLSCHAFT (DE) 2001-04-10 US disclosed
US-6031109-A Phenoxy-, phenylthio-, benzoyl-alkyleneaminoalkylene-imidazole derivatives as therapeutic agents KNOLL AKTIENGESELLSCHAFT (DE) 2000-02-29 US disclosed
US-5780642-A NON-STEROIDAL ANTIINFLAMMATORY AGENT WHICH BLOCKS RELEASE OF ARACHIDONIC ACID FROM PHOSPHOLIPIDS; SIDE EFFECT REDUCTION KNOLL AKTIENGESELLSCHAFT (DE) 1998-07-14 US disclosed
EP-0705251-A1 IMIDAZOLE DERIVATIVES AS THERAPEUTIC AGENTS Knoll AG (DE) 1996-04-10 EP disclosed
WO-1995000493-A1 IMIDAZOLE DERIVATIVES AS THERAPEUTIC AGENTS KNOLL AG (DE) 1995-01-05 WO disclosed