SCHEMBL7868892

SCHEMBL7868892

O=S(=O)(Nc1nc2ccncn2n1)c1cccnc1

nearest known ligand 0.46

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CA2 P00918 1/20 0.46
SLC40A1 Q9NP59 5/20 0.45
GLO1 Q04760 1/20 0.45
KEAP1 Q14145 1/20 0.44
NFE2L2 Q16236 1/20 0.44
MAPT P10636 1/20 0.43
KMT2A Q03164 1/20 0.41
GLA P06280 1/20 0.40
CKS1B P61024 1/20 0.40
SKP2 Q13309 1/20 0.40
SNCA P37840 1/20 0.40
NAMPT P43490 1/20 0.39
BRAF P15056 1/20 0.39
NAPRT Q6XQN6 1/20 0.39
POLB P06746 1/20 0.39
IDO1 P14902 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4064582 0.88 GLA (0.52) MAPTKMT2AGLA
SCHEMBL7865868 0.85 JAK2 (0.49) CA2SLC40A1GLO1KEAP1NFE2L2
SCHEMBL4069365 0.77 GLO1 (0.44) SLC40A1GLO1GLA
SCHEMBL4065421 0.76 HPGD (0.53) GLO1KMT2AGLANAMPT
SCHEMBL6630104 0.71 SLC40A1 (0.36) SLC40A1NAMPT
SCHEMBL21960091 0.70 NAPRT (0.57) SLC40A1GLO1KEAP1NFE2L2MAPT
SCHEMBL4061727 0.70 JAK2 (0.56) KEAP1MAPTKMT2AGLAPOLB
SCHEMBL2565637 0.70 KEAP1 (0.64) SLC40A1GLO1KEAP1NFE2L2KMT2A
SCHEMBL3305989 0.69 JAK2 (0.64) MAPTKMT2APOLB
SCHEMBL3447394 0.68 ALDH1A1 (0.59) SLC40A1GLO1KEAP1NFE2L2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6303814-B1 N-[1,2,4]triazoloazinyl) benzenesulfonamide and pyridinesulfonamide compounds and their use as herbicides DOW AGROSCIENCES LLC 2001-10-16 US disclosed
EP-0877745-B1 N-( 1,2,4] TRIAZOLOAZINYL)BENZENESULFONAMIDE AND PYRIDINESULFONAMIDE COMPOUNDS AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2001-07-25 EP disclosed
US-6130335-A N-([1,2,4]triazoloazinyl) benzenesulfonamide and pyridinesulfonamide compounds and their use as herbicides DOW AGROSCIENCES LLC (US) 2000-10-10 US disclosed
US-6005108-A POST-EMERGENCE TOTAL VEGETATION CONTROL OR SELECTIVE CONTROL OF WEEDS IN WHEAT, RICE AND OIL-SEED RAPE CROPS JOHNSON TIMOTHY C (US) 1999-12-21 US disclosed
US-5965490-A NOVEL COMPOUNDS WITH IMPROVED SELECTIVITY TO VALUABLE CROPS AND IMPROVED TOXICOLOGICAL AND ENVIRONMENTAL ATTRIBUTES; APPLYING TO CONTROL WEEDS BY EITHER PREEMERGENCE OR POSTEMERGENCE APPLICATION DOW AGROSCIENCES LLC (US) 1999-10-12 US disclosed