Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 3/20 | 0.40 |
| ▸ | ACHE | P22303 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7874665 | 0.84 | PPARG (0.47) | PPARGPPARABCHEACHEHTT | |
| SCHEMBL7868078 | 0.80 | PPARG (0.49) | PPARGPPARAACHE | |
| SCHEMBL499557 | 0.79 | OPRK1 (0.43) | PPARGPPARAALOX5 | |
| SCHEMBL7169569 | 0.78 | AOC3 (0.56) | L3MBTL1 | |
| SCHEMBL10110960 | 0.77 | ALOX5 (0.46) | PPARGPPARAL3MBTL1ALOX5 | |
| SCHEMBL8403516 | 0.77 | ALOX5 (0.46) | PPARGPPARAL3MBTL1ALOX5 | |
| SCHEMBL17138190 | 0.76 | KMT2A (0.48) | ACHE | |
| SCHEMBL7868075 | 0.76 | GPR52 (0.42) | PPARGPPARAHTT | |
| SCHEMBL8403375 | 0.75 | CYSLTR2 (0.42) | ALOX5 | |
| SCHEMBL2448081 | 0.74 | L3MBTL1 (0.47) | HTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316405-B1 | CYCLOSPORIN A, POLYPEPTIDES, COMPONENT OF AMYLOID PLAQUES FOUND IN NEUROLOGICAL DISORDERS SUCH AS ALZHEIMER'S DISEASE, MULTIPLE SCLEROSIS, AND AMYOTROPHIC LATERAL SCLEROSIS. THE CONJUGATES ARE USEFUL IN THE TREATMENT OF NEUROLOGICAL | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2001-11-13 | — | — | US | disclosed |