Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR52 | Q9Y2T5 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7868078 | 0.82 | PPARG (0.49) | KMT2APPARGPPARA | |
| SCHEMBL2769996 | 0.78 | MAOA (0.45) | GPR52ALDH1A1MAOAMAOBKDM4E | |
| SCHEMBL17138190 | 0.78 | KMT2A (0.48) | KMT2AMEN1 | |
| SCHEMBL2448081 | 0.76 | L3MBTL1 (0.47) | ALDH1A1KMT2AHTT | |
| SCHEMBL7871801 | 0.76 | PPARG (0.43) | HTTPPARGPPARA | |
| SCHEMBL28096942 | 0.75 | G6PC1 (0.55) | GPR52ALDH1A1MAOAMAOBKDM4E | |
| SCHEMBL2769712 | 0.75 | PPARA (0.53) | ALDH1A1MAOAMAOBKDM4EPKM | |
| SCHEMBL28220738 | 0.74 | ACHE (0.47) | MAOBKMT2AMEN1 | |
| SCHEMBL28389846 | 0.73 | LMNA (0.61) | ALDH1A1KMT2APPARGMEN1 | |
| SCHEMBL27578836 | 0.72 | LMNA (0.50) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316405-B1 | CYCLOSPORIN A, POLYPEPTIDES, COMPONENT OF AMYLOID PLAQUES FOUND IN NEUROLOGICAL DISORDERS SUCH AS ALZHEIMER'S DISEASE, MULTIPLE SCLEROSIS, AND AMYOTROPHIC LATERAL SCLEROSIS. THE CONJUGATES ARE USEFUL IN THE TREATMENT OF NEUROLOGICAL | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2001-11-13 | — | — | US | disclosed |