Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.49 |
| ▸ | PPARA | Q07869 | 5/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 3/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17138190 | 0.82 | KMT2A (0.48) | ACHEKMT2A | |
| SCHEMBL7868075 | 0.82 | GPR52 (0.42) | PPARGPPARAKMT2A | |
| SCHEMBL28220738 | 0.81 | ACHE (0.47) | ACHEKMT2A | |
| SCHEMBL2448081 | 0.80 | L3MBTL1 (0.47) | KMT2A | |
| SCHEMBL7871801 | 0.80 | PPARG (0.43) | PPARGPPARAACHE | |
| SCHEMBL28389846 | 0.77 | LMNA (0.61) | PPARGACHEKMT2A | |
| SCHEMBL27578836 | 0.76 | LMNA (0.50) | ACHEMTNR1AMTNR1BKMT2A | |
| SCHEMBL2769998 | 0.76 | PPARA (0.55) | PPARGPPARAKMT2A | |
| SCHEMBL28161063 | 0.74 | CYP3A4 (0.49) | HDAC1HDAC6KMT2A | |
| SCHEMBL715536 | 0.74 | CYP3A4 (0.56) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316405-B1 | CYCLOSPORIN A, POLYPEPTIDES, COMPONENT OF AMYLOID PLAQUES FOUND IN NEUROLOGICAL DISORDERS SUCH AS ALZHEIMER'S DISEASE, MULTIPLE SCLEROSIS, AND AMYOTROPHIC LATERAL SCLEROSIS. THE CONJUGATES ARE USEFUL IN THE TREATMENT OF NEUROLOGICAL | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2001-11-13 | — | — | US | disclosed |