Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GPR3 | P46089 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11025328 | 0.97 | ESR1 (0.42) | ESR1ESR2TSHRNR1H2NR1H3 | |
| SCHEMBL31711468 | 0.88 | ESR1 (0.41) | ESR1ESR2TSHRNR1H2NR1H3 | |
| SCHEMBL8384123 | 0.81 | ESR1 (0.44) | ESR1ESR2TSHRNR1H2NR1H3 | |
| SCHEMBL242095 | 0.79 | ALDH1A1 (0.40) | ESR1ESR2TSHRACHELMNA | |
| SCHEMBL14666537 | 0.79 | ESR1 (0.42) | ESR1ESR2TSHRNR1H2NR1H3 | |
| SCHEMBL244122 | 0.79 | ESR1 (0.42) | ESR1ESR2TSHRNR1H2NR1H3 | |
| SCHEMBL11025001 | 0.78 | ESR1 (0.38) | ESR1ESR2NR1H2NR1H3MAPT | |
| SCHEMBL2799324 | 0.75 | ESR1 (0.44) | ESR1ESR2TSHRNR1H2NR1H3 | |
| SCHEMBL11023948 | 0.75 | ESR1 (0.44) | ESR1ESR2TSHRNR1H2NR1H3 | |
| SCHEMBL2796775 | 0.75 | ESR1 (0.44) | ESR1ESR2TSHRNR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8575381-B2 | Trihydridosilyl-terminated polysilanes and methods of preparation | GELEST TECHNOLOGIES, INC. (US) | 2013-11-05 | — | — | US | disclosed |
| US-8575381-B2 | Trihydridosilyl-terminated polysilanes and methods of preparation | GELEST TECHNOLOGIES, INC. (US) | 2013-11-05 | — | — | US | disclosed |
| US-8575381-B2 | Trihydridosilyl-terminated polysilanes and methods of preparation | GELEST TECHNOLOGIES, INC. (US) | 2013-11-05 | — | — | US | disclosed |
| US-20120071678-A1 | TRIHYDRIDOSILYL-TERMINATED POLYSILANES AND METHODS OF PREPARATION | GELEST TECHNOLOGIES, INC. (US) | 2012-03-22 | — | — | US | disclosed |
| US-20120071678-A1 | TRIHYDRIDOSILYL-TERMINATED POLYSILANES AND METHODS OF PREPARATION | GELEST TECHNOLOGIES, INC. (US) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071678-A1 | TRIHYDRIDOSILYL-TERMINATED POLYSILANES AND METHODS OF PREPARATION | SI, STT3A, STT3B | ESR1 4842/4885ESR2 4865/4885TSHR 3039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.