Sugi Predict

Sugi Predict / Compounds / SCHEMBL7898210

SCHEMBL7898210

SCHEMBL7898210

CC(C)(C)Oc1cccc(Cl)n1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP3A4 P08684 1/20 0.42
▸ TSHR P16473 1/20 0.42
▸ TRPV3 Q8NET8 1/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.40
▸ KCNH2 Q12809 1/20 0.38
▸ ALOX5AP P20292 1/20 0.35
▸ HTR3E A5X5Y0 2/20 0.34
▸ HTR3B O95264 2/20 0.34
▸ HTR3A P46098 2/20 0.34
▸ HTR3D Q70Z44 2/20 0.34
▸ HTR3C Q8WXA8 2/20 0.34
▸ ALDH1A1 P00352 2/20 0.33
▸ PTGS2 P35354 1/20 0.33
▸ NFE2L2 Q16236 1/20 0.32
▸ IDH1 O75874 4/20 0.31
▸ IDH2 P48735 3/20 0.31
▸ FFAR4 Q5NUL3 1/20 0.31
▸ HDAC1 Q13547 1/20 0.31
▸ HDAC6 Q9UBN7 1/20 0.31
▸ HDAC5 Q9UQL6 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9494178 0.88 CYP3A4 (0.42) CYP3A4TSHRTRPV3L3MBTL1KCNH2
SCHEMBL2522651 0.84 TRPV3 (0.45) TSHRTRPV3KCNH2ALOX5APALDH1A1
SCHEMBL2301721 0.81 TSHR (0.48) CYP3A4TSHRL3MBTL1HTR3EHTR3B
SCHEMBL2302960 0.79 CYP3A4 (0.42) CYP3A4TSHRL3MBTL1HTR3EHTR3B
SCHEMBL2655450 0.78 PPARA (0.49) CYP3A4TSHRL3MBTL1ALDH1A1
SCHEMBL28980448 0.78 IDH1 (0.35) CYP3A4TSHRTRPV3L3MBTL1IDH1
SCHEMBL14545220 0.77 CCR1 (0.44) CYP3A4TSHRTRPV3KCNH2ALOX5AP
SCHEMBL29427046 0.76 — —
SCHEMBL336762 0.76 — —
SCHEMBL17036733 0.75 TRPV3 (0.40) TRPV3KCNH2ALOX5APFFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260115174-A1 PHARMACOLOGICAL CORRECTORS OF RHODOPSIN AND USES THEREOF OCTANT INC (US) 2026-04-30 — — US disclosed
US-20230374017-A1 COMPOSITIONS AND METHODS FOR ACTIVATING PYRUVATE KINASE THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2023-11-23 — — US disclosed
CN-107567443-B Biaryl derivatives as GPR120 agonists 株式会社LG化学 2023-04-28 — — CN disclosed
CN-115925679-A Biaryl derivatives as GPR120 agonists 株式会社LG化学 2023-04-07 — — CN disclosed
EP-3239143-B1 BIARYL DERIVATIVE AS GPR120 AGONIST LG CHEMICAL LTD (KR) 2023-03-22 — — EP disclosed
US-20220135574-A1 BIARYL DERIVATIVE AS GPR120 AGONIST LG CHEM, LTD. (KR) 2022-05-05 — — US disclosed
US-11261186-B2 Biaryl derivative as GPR120 agonist LG CHEM. LTD. (KR) 2022-03-01 — — US disclosed
US-20170349594-A1 BIARYL DERIVATIVE AS GPR120 AGONIST LG CHEM, LTD. (KR) 2017-12-07 — — US disclosed
EP-3239143-A2 BIARYL DERIVATIVE AS GPR120 AGONIST LG Chem, Ltd. (KR) 2017-11-01 — — EP disclosed
US-20160159773-A1 HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-06-09 — — US disclosed
US-20160159773-A1 HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-06-09 — — US disclosed
EP-3029031-A1 HETEROCYCLIC COMPOUND Takeda Pharmaceutical Company Limited (JP) 2016-06-08 — — EP disclosed
US-8637500-B2 Aminopyridine and carboxypyridine compounds as phosphodiesterase 10 inhibitors AMGEN INC. (US) 2014-01-28 — — US disclosed
US-8637500-B2 Aminopyridine and carboxypyridine compounds as phosphodiesterase 10 inhibitors AMGEN INC. (US) 2014-01-28 — — US disclosed
WO-2013010453-A1 CHEMOKING RECEPTOR ANTAGONISTS ABBOTT LABORATORIES (US) 2013-01-24 — — WO disclosed
EP-2376455-B1 AMINOPYRIDINE AND CARBOXYPYRIDINE COMPOUNDS AS PHOSPHODIESTERASE 10 INHIBITORS AMGEN INC (US) 2012-11-14 — — EP disclosed
CN-102452978-A 2-chloro-substituted or unsubstituted aliphatic hydrocarbyloxypyridine and method for producing same CHONGQING KANGDING MEDICAL TECHNOLOGY CO LTD 2012-05-16 — — CN disclosed
WO-2010077992-A1 AMINOPYRIDINE AND CARBOXYPYRIDINE COMPOUNDS AS PHOSPHODIESTERASE 10 INHIBITORS AMGEN INC. (US) 2010-07-08 — — WO disclosed
US-20100160280-A1 AMINOPYRIDINE AND CARBOXYPYRIDINE COMPOUNDS AS PHOSPHODIESTERASE 10 INHIBITORS AMGEN INC. (US) 2010-06-24 — — US disclosed
US-20100160280-A1 AMINOPYRIDINE AND CARBOXYPYRIDINE COMPOUNDS AS PHOSPHODIESTERASE 10 INHIBITORS AMGEN INC. (US) 2010-06-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260115174-A1 PHARMACOLOGICAL CORRECTORS OF RHODOPSIN AND USES THEREOF PDE6D, PDE6H, ADRA1D CYP3A4 1505/4885TSHR 850/4885TRPV3 291/4885
US-20220135574-A1 BIARYL DERIVATIVE AS GPR120 AGONIST GPR119, GLP1R, GIPR CYP3A4 1149/4885TSHR 487/4885TRPV3 923/4885
US-20100160280-A1 AMINOPYRIDINE AND CARBOXYPYRIDINE COMPOUNDS AS PHOSPHODIESTERASE 10 INHIBITORS PDE4A, PDE7A, PDE4D CYP3A4 595/4885TSHR 729/4885TRPV3 4265/4885
US-20160159773-A1 HETEROCYCLIC COMPOUND TYK2, SSB, UACA CYP3A4 3988/4885TSHR 744/4885TRPV3 1145/4885
US-20170349594-A1 BIARYL DERIVATIVE AS GPR120 AGONIST GPR119, GLP1R, GIPR CYP3A4 1149/4885TSHR 487/4885TRPV3 923/4885
US-11261186-B2 Biaryl derivative as GPR120 agonist GPR119, GPR88, FFAR1 CYP3A4 779/4885TSHR 485/4885TRPV3 535/4885
US-20230374017-A1 COMPOSITIONS AND METHODS FOR ACTIVATING PYRUVATE KINASE PCK1, PDK2, PDK1 CYP3A4 3324/4885TSHR 3270/4885TRPV3 3720/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.