Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | CPN1 | P15169 | 1/20 | 0.42 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | MC5R | P33032 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7913433 | 0.93 | GAA (0.50) | MAPK1HSD17B10F2CPN1CPB2 | |
| SCHEMBL19146559 | 0.85 | KDM4E (0.52) | MAPK1HSD17B10F2CPN1CPB2 | |
| SCHEMBL8386026 | 0.83 | ITGB3 (0.40) | MAPK1HSD17B10CPN1CPB2PKM | |
| SCHEMBL10826454 | 0.83 | HSD17B10 (0.48) | HSD17B10PKMITGB3ITGA2BGAA | |
| Tetraxetan SCHEMBL21248095 | 0.82 | HSD17B10 (0.56) | HSD17B10PKMITGB3ITGA2BGAA | |
| SCHEMBL8384455 | 0.79 | PKM (0.45) | MAPK1HSD17B10PKMITGB3ITGA2B | |
| Tetraxetan SCHEMBL18018 | 0.79 | HSD17B10 (0.64) | MAPK1HSD17B10GAAALOX15TSHR | |
| SCHEMBL321989 | 0.79 | HSD17B10 (0.64) | MAPK1HSD17B10GAAALOX15TSHR | |
| SCHEMBL173508 | 0.79 | HSD17B10 (0.64) | MAPK1HSD17B10GAAALOX15TSHR | |
| SCHEMBL6848102 | 0.79 | HSD17B10 (0.64) | MAPK1HSD17B10GAAALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0608759-B1 | Piperazine derivatives | MERCK PATENT GMBH (DE) | 2001-08-22 | — | — | EP | disclosed |
| US-5908843-A | Piperazine compounds as fibrinogen inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-06-01 | — | — | US | disclosed |
| EP-0608759-A2 | Piperazinderivatives | MERCK PATENT GmbH (DE) | 1994-08-03 | — | — | EP | disclosed |