Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CPN1 | P15169 | 1/20 | 0.38 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.38 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.38 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.38 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7900115 | 0.93 | MAPK1 (0.46) | GAAPKMHSD17B10ALOX15TSHR | |
| SCHEMBL8384455 | 0.87 | PKM (0.45) | GAAPKMHSD17B10ALOX15TSHR | |
| SCHEMBL7127595 | 0.87 | GAA (0.64) | GAAPKMHSD17B10ALOX15TSHR | |
| SCHEMBL8384378 | 0.84 | MAPK1 (0.47) | GAAPKMHSD17B10ALOX15TSHR | |
| SCHEMBL8386026 | 0.83 | ITGB3 (0.40) | GAAPKMHSD17B10TSHRALDH1A1 | |
| SCHEMBL7129737 | 0.81 | GAA (0.63) | GAAHSD17B10ALOX15TSHRALDH1A1 | |
| SCHEMBL8382459 | 0.80 | PKM (0.51) | GAAPKMHSD17B10ALOX15TSHR | |
| SCHEMBL5872643 | 0.79 | GAA (0.65) | GAAHSD17B10ALOX15TSHRALDH1A1 | |
| SCHEMBL19146559 | 0.79 | KDM4E (0.52) | GAAPKMHSD17B10ALOX15TSHR | |
| SCHEMBL15499763 | 0.77 | BLM (0.49) | GAAPKMHSD17B10ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0608759-B1 | Piperazine derivatives | MERCK PATENT GMBH (DE) | 2001-08-22 | — | — | EP | disclosed |
| US-5908843-A | Piperazine compounds as fibrinogen inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-06-01 | — | — | US | disclosed |
| EP-0608759-A2 | Piperazinderivatives | MERCK PATENT GmbH (DE) | 1994-08-03 | — | — | EP | disclosed |