SCHEMBL790082

SCHEMBL790082

FC(F)(F)c1[c]c(Cl)ncc1

nearest known ligand 0.36

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
NOS3 P29474 1/20 0.36
NOS2 P35228 1/20 0.36
PIK3CD O00329 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1881445 0.76 NOS3 (0.38) NOS3NOS2
SCHEMBL602198 0.76 NOS3 (0.38) NOS3NOS2
SCHEMBL791272 0.74 NOS3 (0.36) NOS3NOS2
SCHEMBL4168479 0.70 MAPK1 (0.33)
SCHEMBL1045263 0.70
SCHEMBL1706799 0.69 NOS3 (0.33) NOS3NOS2
SCHEMBL22653643 0.69 NOS3 (0.33) NOS3NOS2
SCHEMBL1707520 0.69 NOS3 (0.33) NOS3NOS2
SCHEMBL351296 0.69
SCHEMBL6493586 0.67 KMT2A (0.39) NOS3NOS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2920163-B1 PYRIDYLOXYAL ALKYL CARBOXAMIDES AND THEIR USE AS ENDOPARASITICIDES AND NEMATICIDE BAYER CROPSCIENCE AG (DE) 2018-05-02 EP disclosed
US-9556121-B2 Pyridyloxyalkyl carboxamides and use thereof as endoparasiticides and nematicides BAYER CROPSCIENCE AG (DE) 2017-01-31 US disclosed
EP-2254416-B1 HERBICIDAL COMPOUNDS SYNGENTA LTD (GB) 2016-09-07 EP disclosed
US-20160075653-A1 NEMATICIDAL N-(PHENYLCYCLOALKYL)CARBOXAMIDES AND N-(PHENYLCYCLOALKYL)THIOCARBOXAMIDES BAYER ANIMAL HEALTH GMBH (DE) 2016-03-17 US disclosed
US-20150291524-A1 PYRIDYLOXYALKYL CARBOXAMIDES AND USE THEREOF AS ENDOPARASITICIDES AND NEMATICIDES BAYER CROPSCIENCE AG (DE) 2015-10-15 US disclosed
WO-2015144657-A1 USE OF PYRIDYLOXYALKYLCARBOXAMIDES FOR THE CONTROL OF UNWANTED MICROORGANISMS BAYER CROPSCIENCE AG (DE) 2015-10-01 WO disclosed
EP-2920163-A1 PYRIDYLOXYALKYL CARBOXAMIDES AND USE THEREOF AS ENDOPARASITICIDES AND NEMATICIDES Bayer CropScience AG (DE) 2015-09-23 EP disclosed
US-8987455-B2 Herbicidal compounds SYNGENTA LIMITED (GB) 2015-03-24 US disclosed
US-8962628-B2 Herbicidal 5H-quinoxaline-6-one derivatives detailed description SYNGENTA LIMITED (GB) 2015-02-24 US disclosed
WO-2014076015-A1 PYRIDYLOXYALKYL CARBOXAMIDES AND USE THEREOF AS ENDOPARASITICIDES AND NEMATICIDES BAYER CROPSCIENCE AG (DE) 2014-05-22 WO disclosed
WO-2012062531-A1 HERBICIDAL COMPOUNDS SYNGENTA LIMITED (GB) 2012-05-18 WO disclosed
WO-2012034959-A2 PYRIDINE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS III BASF SE (DE) 2012-03-22 WO disclosed
US-20110034334-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION, INC. (US) 2011-02-10 US disclosed
US-20110021351-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION, INC. (US) 2011-01-27 US disclosed
CN-101959414-A Herbicidal compounds SYNGENTA LTD 2011-01-26 CN disclosed
CN-101945581-A Herbicidal compounds SYNGENTA LTD 2011-01-12 CN disclosed
EP-2254417-A2 HERBICIDAL COMPOUNDS Syngenta Limited (GB) 2010-12-01 EP disclosed
EP-2254416-A2 HERBICIDAL COMPOUNDS Syngenta Limited (GB) 2010-12-01 EP disclosed
WO-2009090402-A2 HERBICIDAL COMPOUNDS SYNGENTA LIMITED (GB) 2009-07-23 WO disclosed
WO-2009090401-A2 HERBICIDAL COMPOUNDS SYNGENTA LIMITED (GB) 2009-07-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160075653-A1 NEMATICIDAL N-(PHENYLCYCLOALKYL)CARBOXAMIDES AND N-(PHENYLCYCLOALKYL)THIOCARBOXAMIDES DNPH1, AADAC, NAAA NOS3 2490/4885NOS2 1952/4885PIK3CD 927/4885
US-20110021351-A1 HERBICIDAL COMPOUNDS DDT, CBR3, TH NOS3 515/4885NOS2 911/4885PIK3CD 1925/4885
US-20110034334-A1 HERBICIDAL COMPOUNDS CYP4Z1, CYP4F3, DDT NOS3 212/4885NOS2 364/4885PIK3CD 1542/4885
US-20150291524-A1 PYRIDYLOXYALKYL CARBOXAMIDES AND USE THEREOF AS ENDOPARASITICIDES AND NEMATICIDES PLPBP, PFAS, PGLS NOS3 3327/4885NOS2 3409/4885PIK3CD 788/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.