Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.51 |
| ▸ | PDE4A | P27815 | 6/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7634998 | 0.92 | ACHE (0.68) | ACHEMAPTKDM4EGAAL3MBTL1 | |
| SCHEMBL805356 | 0.89 | MAPT (0.61) | ACHEMAPTKDM4EGAAL3MBTL1 | |
| SCHEMBL11963234 | 0.84 | ACHE (0.63) | ACHEMAPTKDM4EGAAL3MBTL1 | |
| SCHEMBL11963361 | 0.82 | ACHE (0.61) | ACHEMAPTKDM4EL3MBTL1PDE4B | |
| SCHEMBL29403877 | 0.82 | ACHE (1.00) | ACHEMAPTKDM4EGAAL3MBTL1 | |
| SCHEMBL12518 | 0.82 | ACHE (1.00) | ACHEMAPTKDM4EGAAL3MBTL1 | |
| SCHEMBL12408754 | 0.82 | ACHE (0.65) | ACHEMAPTKDM4EGAAL3MBTL1 | |
| SCHEMBL11354738 | 0.81 | ALDH1A1 (0.75) | ACHEMAPTKDM4EGAAL3MBTL1 | |
| SCHEMBL16502112 | 0.80 | MAPT (0.61) | MAPTKDM4EGAAL3MBTL1HPGD | |
| SCHEMBL12781858 | 0.80 | ACHE (0.63) | ACHEMAPTKDM4EGAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021139651-A1 | BIOMASS INTRINSIC FLAME-RETARDANT HIGH-TEMPERATURE-RESISTANT EPOXY RESIN AND PREPARATION METHOD THEREFOR | 厦门大学 | 2021-07-15 | — | — | WO | disclosed |
| US-9944599-B2 | Processes for the preparation of beta-aminosulfone compounds | LEK PHARMACEUTICALS (SI) | 2018-04-17 | — | — | US | disclosed |
| EP-3252050-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |
| EP-3252049-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |
| US-20170174627-A1 | Processes For The Preparation Of Beta-Aminosulfone Compounds | LEK PHARMACEUTICALS D.D. (SI) | 2017-06-22 | — | — | US | disclosed |
| WO-2017094031-A2 | NOVEL PROCESS FOR PREPARATION OF APREMILAST | SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) | 2017-06-08 | — | — | WO | disclosed |
| US-20170145011-A1 | Pyrrolopyrazine-Spirocyclic piperidine amides as modulators of ion channels | VERTEX PHARMA (US) | 2017-05-25 | — | — | US | disclosed |
| US-9511067-B2 | Substituted spiro[piperidine-4,1'-pyrrolo[1,2-a]pyrazine]s as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2016-12-06 | — | — | US | disclosed |
| EP-2595989-B1 | HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2016-07-13 | — | — | EP | disclosed |
| US-9365588-B2 | Benzoxazines as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2016-06-14 | — | — | US | disclosed |
| US-7342115-B2 | Binding antagonist and arylpyridine for antiinflammatory agents, cardiovascular disorders and antagonist or agonist and for immunology | NEUROGEN CORPORATION (US) | 2008-03-11 | — | — | US | disclosed |
| US-20080015199-A1 | Triazolone derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-01-17 | — | — | US | disclosed |
| US-20070238758-A1 | Agent for inhibition of cytokine production and agent for inhibition of cell adhesion | OTSUKA PHARMACEUTICAL CO., LTD. | 2007-10-11 | — | — | US | disclosed |
| US-7279469-B2 | Diaminotriazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-09 | — | — | US | disclosed |
| WO-2007103554-A1 | QUINOLINE AND ISOQUINOLINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2007-09-13 | — | — | WO | disclosed |
| WO-2007098214-A1 | CINNOLINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2007-08-30 | — | — | WO | disclosed |
| US-7241780-B2 | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method | BRISTOLS-MYERS SQUIBB COMPANY (US) | 2007-07-10 | — | — | US | disclosed |
| US-20070105911-A1 | Agent for inhibition of cytokine production and agent for inhibition of cell adhesion | CHIHIRO MASATOSHI | 2007-05-10 | — | — | US | disclosed |
| US-20070015797-A1 | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method | CHENG PETER T | 2007-01-18 | — | — | US | disclosed |
| US-3950236-A | OXIDATION, ALKYL-ALKOXY-BIBENZYL COMPOUNDS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF HEALTH, EDUCATION AND WELFARE (US) | 1976-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170145011-A1 | Pyrrolopyrazine-Spirocyclic piperidine amides as modulators of ion channels | KCNJ2, KCNJ5, KCNJ1 | ACHE 1784/4885MAPT 2311/4885KDM4E 2838/4885 |
| US-20070238758-A1 | Agent for inhibition of cytokine production and agent for inhibition of cell adhesion | IL2, IL1RN, SELL | ACHE 4454/4885MAPT 4492/4885KDM4E 3406/4885 |
| US-20170174627-A1 | Processes For The Preparation Of Beta-Aminosulfone Compounds | TPMT, MPST, CBS | ACHE 555/4885MAPT 1457/4885KDM4E 1831/4885 |
| US-20070105911-A1 | Agent for inhibition of cytokine production and agent for inhibition of cell adhesion | IL2, IL1RN, SELL | ACHE 4462/4885MAPT 4491/4885KDM4E 3397/4885 |
| US-20070015797-A1 | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method | GPR119, LIPC, ACACA | ACHE 3502/4885MAPT 4848/4885KDM4E 2164/4885 |
| US-20080015199-A1 | Triazolone derivatives | F3, F12, F2 | ACHE 4696/4885MAPT 3959/4885KDM4E 3720/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.