Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | BTK | Q06187 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL789915 | 0.93 | RAB9A (0.50) | KDRRAB9ANPC1BTKLMNA | |
| SCHEMBL790093 | 0.90 | SMN1; SMN2 (0.48) | KDRRAB9ANPC1LMNATP53 | |
| SCHEMBL790646 | 0.87 | KDR (0.47) | KDRRAB9ALMNAMAPT | |
| SCHEMBL791145 | 0.85 | KDR (0.46) | KDRRAB9ANPC1LMNATP53 | |
| SCHEMBL790416 | 0.85 | MRGPRX4 (0.50) | KDRRAB9ALMNAMAPTLRRK2 | |
| SCHEMBL791199 | 0.84 | RAB9A (0.50) | KDRRAB9ALMNA | |
| SCHEMBL789721 | 0.81 | MAPK14 (0.51) | RAB9ANPC1BTKMAPTSMN1; SMN2 | |
| SCHEMBL790621 | 0.79 | KDR (0.46) | KDRRAB9ANPC1LMNAMAPT | |
| SCHEMBL789889 | 0.78 | RAB9A (0.48) | KDRRAB9AMAPK1 | |
| SCHEMBL790788 | 0.72 | NPC1 (0.54) | RAB9ANPC1BTKMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |