Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | STAT6 | P42226 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL789915 | 0.92 | RAB9A (0.50) | KDRAURKBRAB9ALRRK2CTNNB1 | |
| SCHEMBL790093 | 0.88 | SMN1; SMN2 (0.48) | KDRRAB9AKMT2AMEN1MAPT | |
| SCHEMBL790621 | 0.88 | KDR (0.46) | KDRRAB9ACTNNB1TCF7L2CLK1 | |
| SCHEMBL790392 | 0.85 | KDR (0.48) | KDRAURKBRAB9ALRRK2MAPT | |
| SCHEMBL790416 | 0.83 | MRGPRX4 (0.50) | KDRRAB9ALRRK2CLK1DYRK1A | |
| SCHEMBL789889 | 0.83 | RAB9A (0.48) | KDRRAB9ACLK1DYRK1APIK3CA | |
| SCHEMBL790553 | 0.81 | ATR (0.49) | RAB9AMAPTNPC1MAPK1TP53 | |
| SCHEMBL790646 | 0.81 | KDR (0.47) | KDRRAB9AKMT2AMEN1MAPT | |
| SCHEMBL791199 | 0.79 | RAB9A (0.50) | KDRRAB9ACLK1DYRK1APIK3CA | |
| SCHEMBL790788 | 0.72 | NPC1 (0.54) | RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |