SCHEMBL7916277

SCHEMBL7916277

C=CCc1ccc(NC(C)=O)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 0.53
HTT P42858 1/20 0.53
L3MBTL1 Q9Y468 1/20 0.53
TSHR P16473 2/20 0.53
KMT2A Q03164 5/20 0.52
ALDH1A1 P00352 4/20 0.52
MEN1 O00255 4/20 0.52
MAPT P10636 3/20 0.52
TDP1 Q9NUW8 2/20 0.52
CA12 O43570 1/20 0.52
BRD4 O60885 1/20 0.52
NR1I2 O75469 1/20 0.52
CA1 P00915 1/20 0.52
CA2 P00918 1/20 0.52
MB P02144 1/20 0.52
CYP1A1 P04798 1/20 0.52
CA3 P07451 1/20 0.52
CYP3A4 P08684 1/20 0.52
RARG P13631 1/20 0.52
ALOX5AP P20292 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13598484 0.85 SMN1; SMN2 (0.57) SMN1; SMN2HTTL3MBTL1TSHRKMT2A
SCHEMBL6285087 0.84 RXFP1 (0.54) SMN1; SMN2L3MBTL1TSHRALDH1A1MAPT
SCHEMBL27808997 0.83 SMN1; SMN2 (0.55) SMN1; SMN2HTTL3MBTL1TSHRKMT2A
SCHEMBL11134234 0.83 TGM2 (0.43) SMN1; SMN2TSHRKMT2AALDH1A1MEN1
SCHEMBL16092931 0.81 SMN1; SMN2 (0.53) SMN1; SMN2HTTL3MBTL1TSHRKMT2A
SCHEMBL28268244 0.81 SMN1; SMN2 (0.53) SMN1; SMN2HTTL3MBTL1TSHRKMT2A
SCHEMBL6279031 0.81 TGM2 (0.59) HSD17B10LMNACYP1A2
SCHEMBL7754428 0.81 PEPD (0.52) SMN1; SMN2TSHRKMT2AALDH1A1MEN1
SCHEMBL11774737 0.81 CYP1A2 (0.41) SMN1; SMN2TSHRKMT2AALDH1A1MEN1
SCHEMBL839533 0.80 SMN1; SMN2 (0.61) SMN1; SMN2HTTL3MBTL1TSHRKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140243547-A1 LINEAR (PER) FLUOROPOLYETHERS WITH -CF(CF3)COF END GROUPS AND DERIVATIVES THEREOF SOLVAY SPECIALTY POLYMERS ITALY S.P.A. (IT) 2014-08-28 US disclosed
WO-2013050273-A1 LINEAR (PER)FLUOROPOLYETHERS WITH -CF(CF3)COF END GROUPS AND DERIVATIVES THEREOF SOLVAY SPECIALTY POLYMERS ITALY S.P.A. (IT) 2013-04-11 WO disclosed
US-8278256-B2 Fluorinated lubricants SOLVAY SOLEXIS S.P.A. (IT) 2012-10-02 US disclosed
US-8217119-B2 Additives for halopolymers SOLVAY SOLEXIS S.P.A. (IT) 2012-07-10 US disclosed
US-20100069275-A1 Fluorinated lubricants SOLVAY SOLEXIS S.P.A. (IT) 2010-03-18 US disclosed
US-20090326154-A1 Additives for Halopolymers SOLVAY SOLEXIS S.P.A. (IT) 2009-12-31 US disclosed
US-7629483-B2 Peroxidic perfluoropolyethers SOLVAY SOLEXIS S.P.A. (IT) 2009-12-08 US disclosed
US-20080194881-A1 Copolymers having functional end groups of sulfonyl fluorides and acyl fluorides; macromer promoters useful for both condensation and addition polymerizations for elastomers and polymershaving a crystal structure; mechanical properties; lubricants for magnetic disks; adhesives SOLVAY SOLEXIS S.P.A. (IT) 2008-08-14 US disclosed
US-7371900-B2 Peroxidic perfluoropolyethers SOLVAY SOLEXIS S.P.A. (IT) 2008-05-13 US disclosed
US-7365229-B2 Peroxidic perfluoropolyethers SOLVAY SOLEXIS S.P.A. (IT) 2008-04-29 US disclosed
US-6232430-B1 PYRROLIDIN-2,5-DIONE COMPOUND JDS UNIPHASE PHOTONICS C.V. (NL) 2001-05-15 US disclosed
EP-0934266-A1 CROSS-LINKERS FOR CROSS-LINKABLE OPTICAL POLYCARBONATES Akzo Nobel N.V. (NL) 1999-08-11 EP disclosed
WO-1998017644-A1 CROSS-LINKERS FOR CROSS-LINKABLE OPTICAL POLYCARBONATES AKZO NOBEL N.V. (NL) 1998-04-30 WO disclosed
US-5171676-A Hydroxylation with Beauveria sulfurescens, while preserving peroxide linkage; antimalarial agents THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1992-12-15 US disclosed
US-4173544-A SOLVENT- AND OXYGEN-FREE CONDENSATION OF AN ALKYL-ANILINE AND -BENALDEHYDE BBC BROWN BOVERI & COMPANY LIMITED (CH) 1979-11-06 US disclosed
US-4060491-A 5-ALKYL BENZOTRIAZOLE MOBIL OIL CORPORATION (US) 1977-11-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140243547-A1 LINEAR (PER) FLUOROPOLYETHERS WITH -CF(CF3)COF END GROUPS AND DERIVATIVES THEREOF COXFA4, CYP4F3, ETFB SMN1; SMN2 2771/4885HTT 2320/4885L3MBTL1 4386/4885
US-20080194881-A1 Copolymers having functional end groups of sulfonyl fluorides and acyl fluorides; macromer promoters useful for both condensation and addition polymerizations for elastomers and polymershaving a crystal structure; mechanical properties; lubricants for magnetic disks; adhesives FOXO1, FOXM1, F12 SMN1; SMN2 513/4885HTT 2792/4885L3MBTL1 2259/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.