Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 3/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CTSC | P53634 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GHSR | Q92847 | 2/20 | 0.31 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.30 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7931036 | 0.72 | GHSR (0.32) | GHSR | |
| SCHEMBL6942735 | 0.67 | ADAM17 (0.42) | ADAM17MMP1MMP9MMP13HTR2A | |
| SCHEMBL7957560 | 0.67 | GHSR (0.37) | ADAM17HTR2ATSHRCTSCGHSR | |
| SCHEMBL6940930 | 0.66 | ADAM17 (0.40) | ADAM17MMP1MMP9MMP13CTSC | |
| SCHEMBL7931077 | 0.65 | ADAM17 (0.34) | ADAM17HTR2ACTSCGAASMN1; SMN2 | |
| SCHEMBL6942460 | 0.64 | ADAM17 (0.46) | ADAM17MMP1HTR2ACTSCGRIK1 | |
| SCHEMBL6945084 | 0.64 | ADAM17 (0.42) | ADAM17MMP1MMP9MMP13HTR2A | |
| SCHEMBL7103597 | 0.62 | ADAM17 (0.48) | ADAM17MMP1MMP9MMP13HTR2A | |
| SCHEMBL7107632 | 0.62 | ADAM17 (0.48) | ADAM17MMP1MMP9MMP13HTR2A | |
| SCHEMBL27947171 | 0.61 | HTR2A (0.53) | HTR2ACTSCGRIK1GRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |