Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | LOX | P28300 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18034192 | 0.80 | CA2 (0.36) | CA2ALDH1A1KMT2AHTTGAA | |
| Water SCHEMBL7042206 | 0.78 | CA2 (0.35) | CA2ALDH1A1KMT2AHTTGAA | |
| SCHEMBL15711923 | 0.78 | CA2 (0.47) | CA2ALDH1A1KMT2AHTTGAA | |
| SCHEMBL9780984 | 0.78 | PSIP1 (0.55) | CA2LOXPSIP1 | |
| SCHEMBL10787889 | 0.77 | MMP2 (0.47) | CA2ALDH1A1KMT2AHTTGAA | |
| SCHEMBL10700258 | 0.77 | LMNA (0.45) | CA2ALDH1A1KMT2AHTTGAA | |
| SCHEMBL9341921 | 0.75 | CA2 (0.51) | CA2ALDH1A1KMT2ALOXCYP2C19 | |
| SCHEMBL8818862 | 0.74 | CA2 (0.39) | CA2ALDH1A1KMT2AHTTGAA | |
| SCHEMBL314732 | 0.74 | TSHR (0.50) | CA2ALDH1A1GAALMNACYP3A4 | |
| SCHEMBL2685459 | 0.74 | ALDH1A1 (0.60) | ALDH1A1KMT2AGAAMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6222067-B1 | CAN BE USED TO SYNTHESIS MANY KINDS OF DYESTUFFS | EVERLIGHT USA, INC. | 2001-04-24 | — | — | US | disclosed |