Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 1/20 | 0.33 |
| ▸ | MASP2 | O00187 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.31 |
| ▸ | HTR2A | P28223 | 3/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.30 |
| ▸ | MGLL | Q99685 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7930219 | 0.84 | TGFBR1 (0.31) | CTSCMASP2TGFBR1P2RX3 | |
| SCHEMBL7937125 | 0.80 | ALDH1A1 (0.31) | CTSCSLC6A3TGFBR1 | |
| SCHEMBL6944569 | 0.79 | SLC6A3 (0.32) | SLC6A3 | |
| SCHEMBL6941960 | 0.79 | ADAM17 (0.33) | CTSCMASP2TGFBR1P2RX3MGLL | |
| SCHEMBL7928806 | 0.78 | P2RX3 (0.34) | CTSCMASP2SLC6A3TGFBR1P2RX3 | |
| SCHEMBL6944688 | 0.77 | P2RX3 (0.31) | CTSCTGFBR1P2RX3 | |
| SCHEMBL6944685 | 0.76 | ADAM17 (0.34) | CTSCMASP2TGFBR1P2RX3 | |
| SCHEMBL8112771 | 0.76 | SLC6A3 (0.31) | SLC6A3TGFBR1P2RX3 | |
| SCHEMBL7819016 | 0.76 | TGFBR1 (0.32) | CTSCTGFBR1P2RX3 | |
| SCHEMBL7933428 | 0.75 | P2RX3 (0.33) | CTSCSLC6A3TGFBR1P2RX3MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |