Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | CTSC | P53634 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.31 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6944688 | 0.83 | P2RX3 (0.31) | P2RX3CTSCTGFBR1CCNA2CDK2 | |
| SCHEMBL7933480 | 0.80 | KDM4E (0.33) | TGFBR1SLC6A3 | |
| SCHEMBL6983937 | 0.80 | ADAM17 (0.42) | P2RX3CTSCTGFBR1MGLLSLC6A3 | |
| SCHEMBL6984895 | 0.78 | CTSC (0.33) | P2RX3CTSCTGFBR1MGLL | |
| SCHEMBL6948116 | 0.76 | TGFBR1 (0.32) | P2RX3CTSCTGFBR1MGLL | |
| SCHEMBL7930228 | 0.75 | CTSC (0.33) | P2RX3CTSCTGFBR1MGLLSLC6A3 | |
| SCHEMBL6941960 | 0.75 | ADAM17 (0.33) | P2RX3CTSCTGFBR1MGLLCCNA2 | |
| SCHEMBL7937958 | 0.75 | P2RX3 (0.31) | P2RX3TGFBR1 | |
| SCHEMBL7928806 | 0.75 | P2RX3 (0.34) | P2RX3CTSCTGFBR1MGLLSLC6A3 | |
| SCHEMBL7940268 | 0.75 | P2RX3 (0.30) | P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |