Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA7 | P43166 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 2/20 | 0.31 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.31 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6939576 | 0.89 | ADAM17 (0.40) | SMN1; SMN2PSMB5MMP13MAPT | |
| SCHEMBL7928755 | 0.76 | PSMB5 (0.46) | SMN1; SMN2PSMB5MAPT | |
| SCHEMBL6945114 | 0.75 | ADAM17 (0.37) | PSMB5MAPTGAAKDM4E | |
| SCHEMBL6947989 | 0.73 | MMP1 (0.46) | MMP2MMP9SMN1; SMN2PSMB5MMP13 | |
| SCHEMBL6942897 | 0.71 | ADAM17 (0.40) | LMNAHTT | |
| SCHEMBL6941589 | 0.69 | ADAM17 (0.49) | MMP2PSMB5GAA | |
| SCHEMBL6941765 | 0.62 | ADAM17 (0.52) | MMP2MMP9MMP13 | |
| SCHEMBL7215705 | 0.62 | ALDH1A1 (0.47) | MMP2MMP9MMP13MAPT | |
| SCHEMBL7215717 | 0.62 | ALDH1A1 (0.47) | MMP2MMP9MMP13MAPT | |
| SCHEMBL5967409 | 0.62 | GAA (0.42) | SMN1; SMN2AKT1GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |