Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 4/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | EED | O75530 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | TIPARP | Q7Z3E1 | 2/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL798567 | 0.81 | CYP17A1 (0.44) | — | |
| SCHEMBL798005 | 0.77 | CYP11B2 (0.45) | CYP11B2HTR2AHTR2CHTR2BCYP11B1 | |
| SCHEMBL798810 | 0.75 | HTR2A (0.34) | CYP11B2HTR2AHTR2CHTR2BEED | |
| SCHEMBL22669012 | 0.69 | NOTUM (0.48) | MAPTHTTKDR | |
| SCHEMBL793474 | 0.69 | CYP11B2 (0.41) | CYP11B2HTR2AHTR2CHTR2BLMNA | |
| SCHEMBL22668992 | 0.68 | NOTUM (0.47) | MAPTHTTKDR | |
| SCHEMBL794441 | 0.68 | CYP11B2 (0.44) | CYP11B2HTR2AHTR2CHTR2BCYP11B1 | |
| SCHEMBL807799 | 0.68 | CYP11B2 (0.57) | CYP11B2HTR2AHTR2CCYP11B1OPRM1 | |
| SCHEMBL794272 | 0.67 | PHGDH (0.43) | HTR2AHTR2CPDGFRBKDR | |
| SCHEMBL793875 | 0.67 | TRPV3 (0.41) | HTR2AHTR2CPDGFRBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627648-A1 | 17aHYDROXYLASE/C17,20-LYASE INHIBITORS | Novartis AG (CH) | 2013-08-21 | — | — | EP | disclosed |
| WO-2012035078-A1 | 17α-HYDROXYLASE/C17,20-LYASE INHIBITORS | NOVARTIS AG (CH) | 2012-03-22 | — | — | WO | disclosed |