Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8111767 | 0.86 | GAA (0.33) | GAASMN1; SMN2 | |
| SCHEMBL6941960 | 0.82 | ADAM17 (0.33) | GAACCNA2CDK2CCNA1CDK5 | |
| SCHEMBL7928806 | 0.81 | P2RX3 (0.34) | GAACCNA2CDK2CCNA1CDK5 | |
| SCHEMBL7937958 | 0.78 | P2RX3 (0.31) | — | |
| SCHEMBL7940268 | 0.77 | P2RX3 (0.30) | — | |
| SCHEMBL8107435 | 0.76 | KMT2A (0.31) | — | |
| SCHEMBL7937824 | 0.74 | SMN1; SMN2 (0.33) | SMN1; SMN2 | |
| SCHEMBL6946852 | 0.74 | ADAM17 (0.40) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL7940281 | 0.72 | CCNA2 (0.31) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL6946415 | 0.71 | GAA (0.35) | GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |